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The Amazing Acrobat: Yeast’s Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance

The Shmunis School of Biomedicine & Cancer Research, Tel Aviv University, Ramat Aviv 69978, Israel
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Academic Editor: Thorsten Allers
Genes 2021, 12(3), 342; https://doi.org/10.3390/genes12030342
Received: 9 February 2021 / Revised: 22 February 2021 / Accepted: 23 February 2021 / Published: 25 February 2021
(This article belongs to the Special Issue Mechanisms of DNA Damage, Repair and Mutagenesis)
Acetylation on lysine 56 of histone H3 of the yeast Saccharomyces cerevisiae has been implicated in many cellular processes that affect genome stability. Despite being the object of much research, the complete scope of the roles played by K56 acetylation is not fully understood even today. The acetylation is put in place at the S-phase of the cell cycle, in order to flag newly synthesized histones that are incorporated during DNA replication. The signal is removed by two redundant deacetylases, Hst3 and Hst4, at the entry to G2/M phase. Its crucial location, at the entry and exit points of the DNA into and out of the nucleosome, makes this a central modification, and dictates that if acetylation and deacetylation are not well concerted and executed in a timely fashion, severe genomic instability arises. In this review, we explore the wealth of information available on the many roles played by H3K56 acetylation and the deacetylases Hst3 and Hst4 in DNA replication and repair. View Full-Text
Keywords: chromatin; acetylation/deacetylation; genome stability; DNA replication; DNA repair; Hst3; Hst4 chromatin; acetylation/deacetylation; genome stability; DNA replication; DNA repair; Hst3; Hst4
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MDPI and ACS Style

Gershon, L.; Kupiec, M. The Amazing Acrobat: Yeast’s Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance. Genes 2021, 12, 342. https://doi.org/10.3390/genes12030342

AMA Style

Gershon L, Kupiec M. The Amazing Acrobat: Yeast’s Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance. Genes. 2021; 12(3):342. https://doi.org/10.3390/genes12030342

Chicago/Turabian Style

Gershon, Lihi, and Martin Kupiec. 2021. "The Amazing Acrobat: Yeast’s Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance" Genes 12, no. 3: 342. https://doi.org/10.3390/genes12030342

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