Next Article in Journal
Mitochondrial Genomes of the Genus Claassenia (Plecoptera: Perlidae) and Phylogenetic Assignment to Subfamily Perlinae
Previous Article in Journal
First Description of the Mitogenome and Phylogeny of Culicinae Species from the Amazon Region
Previous Article in Special Issue
Polly Wants a Genome: The Lack of Genetic Testing for Pet Parrot Species
Article

Identification of W13 in the American Miniature Horse and Shetland Pony Populations

1
Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California–Davis, Davis, CA 95616, USA
2
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California–Davis, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Eric Barrey
Genes 2021, 12(12), 1985; https://doi.org/10.3390/genes12121985
Received: 25 November 2021 / Revised: 7 December 2021 / Accepted: 11 December 2021 / Published: 14 December 2021
(This article belongs to the Special Issue The Role of Genetics and Genomics in Companion Animal Reproduction)
Coat color is a trait of economic significance in horses. Variants in seven genes have been documented to cause white patterning in horses. Of the 34 variants that have been identified in KIT proto-oncogene, receptor tyrosine kinase (KIT), 27 have only been reported in a single individual or family and thus not all are routinely offered for genetic testing. Therefore, to enable proper use of marker-assisted selection, determining breed specificity for these alleles is warranted. Screening 19 unregistered all-white Shetland ponies for 16 white patterning markers identified 14 individuals whose phenotype could not be explained by testing results. In evaluating other known dominant white variants, 14 horses were heterozygous for W13. W13 was previously only reported in two quarter horses and a family of Australian miniature horses. Genotyping known white spotting variants in 30 owner-reported white animals (25 Miniature Horses and five Shetland ponies) identified two additional W13/N American Miniature Horses. The estimated allele frequency of W13 in the American Miniature Horse was 0.0063 (79 N/N, 1 W13/N) and the allele was not detected in a random sample (n = 59) of Shetland ponies. No homozygous W13 individuals were identified and W13/N ponies had a similar all-white coat with pink skin phenotype, regardless of the other white spotting variants present, demonstrating that W13 results in a Mendelian inherited dominant white phenotype and homozygosity is likely lethal. These findings document the presence of W13 in the American Miniature Horse and Shetland pony populations at a low frequency and illustrate the importance of testing for this variant in additional breeds. View Full-Text
Keywords: KIT; dominant white; white spotting; coat color; pigmentation; horse KIT; dominant white; white spotting; coat color; pigmentation; horse
Show Figures

Figure 1

MDPI and ACS Style

Esdaile, E.; Kallenberg, A.; Avila, F.; Bellone, R.R. Identification of W13 in the American Miniature Horse and Shetland Pony Populations. Genes 2021, 12, 1985. https://doi.org/10.3390/genes12121985

AMA Style

Esdaile E, Kallenberg A, Avila F, Bellone RR. Identification of W13 in the American Miniature Horse and Shetland Pony Populations. Genes. 2021; 12(12):1985. https://doi.org/10.3390/genes12121985

Chicago/Turabian Style

Esdaile, Elizabeth, Angelica Kallenberg, Felipe Avila, and Rebecca R. Bellone. 2021. "Identification of W13 in the American Miniature Horse and Shetland Pony Populations" Genes 12, no. 12: 1985. https://doi.org/10.3390/genes12121985

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop