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Investigation of Cerebellar Abiotrophy (CA), Lavender Foal Syndrome (LFS), and Severe Combined Immunodeficiency (SCID) Variants in a Cohort of Three MENA Region Horse Breeds

1
Department of Environment and Biological Sciences, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia 06000, Algeria
2
Faculty of Applied Sciences, University of Applied Sciences Europe, 10963 Berlin, Germany
3
Department of Agronomic and Biotechnological Sciences, Faculty of Nature and Life Sciences, University H. Benbouali, Chlef 02000, Algeria
4
Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Antonio Figueras
Genes 2021, 12(12), 1893; https://doi.org/10.3390/genes12121893
Received: 22 September 2021 / Revised: 22 November 2021 / Accepted: 25 November 2021 / Published: 26 November 2021
(This article belongs to the Section Animal Genetics and Genomics)
Genetic disorders in horses are mostly fatal or usually cause significant economic losses for breeders and owners. Here we studied a total of 177 Arabian, Barb and Arab-Barb horses from the Middle East and North Africa (MENA) using Sanger Sequencing and PCR-ACRS (polymerase chain reaction—artificially created restriction site) approaches to examine the genetic disorders in the studied horse breeds. We identified the genetic variations related to Cerebellar Abiotrophy (CA), Severe Combined Immunodeficiency (SCID) occurrence, and the studied population was free of the mutant allele determined Lavender Foal Syndrome (LFS). Overall, presented data showed that 15 of the studied horses are carriers of two genetic disorders; the investigated horse population showed that five Arabian horses were heterozygous for the CA-associated SNP (rs397160943). The SCID-deletion TCTCA within PRKDC was detected in ten horses (nine Arabian horses and one Arab-Barb horse). This investigation shows the importance of testing these breeds for genetic disorders to avoid further spread of deleterious variants View Full-Text
Keywords: genetic disorders; Arabian horses; Barb horses; Arab-Barb horses; CA; LFS; SCID; molecular biology genetic disorders; Arabian horses; Barb horses; Arab-Barb horses; CA; LFS; SCID; molecular biology
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MDPI and ACS Style

Ayad, A.; Almarzook, S.; Besseboua, O.; Aissanou, S.; Piórkowska, K.; Musiał, A.D.; Stefaniuk-Szmukier, M.; Ropka-Molik, K. Investigation of Cerebellar Abiotrophy (CA), Lavender Foal Syndrome (LFS), and Severe Combined Immunodeficiency (SCID) Variants in a Cohort of Three MENA Region Horse Breeds. Genes 2021, 12, 1893. https://doi.org/10.3390/genes12121893

AMA Style

Ayad A, Almarzook S, Besseboua O, Aissanou S, Piórkowska K, Musiał AD, Stefaniuk-Szmukier M, Ropka-Molik K. Investigation of Cerebellar Abiotrophy (CA), Lavender Foal Syndrome (LFS), and Severe Combined Immunodeficiency (SCID) Variants in a Cohort of Three MENA Region Horse Breeds. Genes. 2021; 12(12):1893. https://doi.org/10.3390/genes12121893

Chicago/Turabian Style

Ayad, Abdelhanine, Saria Almarzook, Omar Besseboua, Sofiane Aissanou, Katarzyna Piórkowska, Adrianna D. Musiał, Monika Stefaniuk-Szmukier, and Katarzyna Ropka-Molik. 2021. "Investigation of Cerebellar Abiotrophy (CA), Lavender Foal Syndrome (LFS), and Severe Combined Immunodeficiency (SCID) Variants in a Cohort of Three MENA Region Horse Breeds" Genes 12, no. 12: 1893. https://doi.org/10.3390/genes12121893

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