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Article

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

1
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
2
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
3
Department of Physical Education and Physiotherapy, Opole University of Technology, 45-758 Opole, Poland
4
Institute of Physical Culture Sciences, University of Szczecin, 70-453 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Italia Di Liegro
Genes 2021, 12(10), 1641; https://doi.org/10.3390/genes12101641
Received: 19 September 2021 / Revised: 12 October 2021 / Accepted: 14 October 2021 / Published: 19 October 2021
(This article belongs to the Special Issue Genetics and Genomics in Sport)
Swimmers’ competitive performance is a result of complicated interactions between physiological, biochemical, physical and psychological factors, all of which are strongly affected by water. Recently, great attention has been paid to the role of genetic factors such as the catechol-O-methyltransferase gene (COMT) influencing motivation, emotions, stress tolerance, self-control, sleep regulation, pain processing and perception, addictive behaviour and neurodegeneration, which may underlie differences in achieving remarkable results in sports competition. Thus, this study was performed to investigate the association between the COMT Val158Met (rs4680) polymorphism and athletic performance in Caucasian swimmers. A total of 225 swimmers (171 short distance (SDS) and 54 long distance swimmers (LDS)) of national or international competitive standard and 379 unrelated sedentary controls were genotyped using real-time polymerase chain reaction (real-time PCR). We found no significant differences in genotypic or allelic distributions between (1) male and female athletes; (2) SDS and LDS; (3) all athletes and sedentary controls (under codominant, dominant, recessive, and overdominant genetic models). No association was found between the COMT rs4680 polymorphism and elite swimming athlete status of the studied population. However, more replication studies are needed. View Full-Text
Keywords: swimming; sport genetics; polymorphism; dopamine; cognitive abilities swimming; sport genetics; polymorphism; dopamine; cognitive abilities
MDPI and ACS Style

Zmijewski, P.; Leońska-Duniec, A.; Stuła, A.; Sawczuk, M. Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance. Genes 2021, 12, 1641. https://doi.org/10.3390/genes12101641

AMA Style

Zmijewski P, Leońska-Duniec A, Stuła A, Sawczuk M. Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance. Genes. 2021; 12(10):1641. https://doi.org/10.3390/genes12101641

Chicago/Turabian Style

Zmijewski, Piotr, Agata Leońska-Duniec, Aleksander Stuła, and Marek Sawczuk. 2021. "Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance" Genes 12, no. 10: 1641. https://doi.org/10.3390/genes12101641

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