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Genes and Weightlifting Performance

Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan
Faculty of Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 5AF, UK
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia
Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, 420010 Kazan, Russia
Department of Physical Culture and Sport, Kazan National Research Technical University Named after A.N. Tupolev-KAI, 420111 Kazan, Russia
Faculty of Medical Science, Nippon Sport Science University, Tokyo 158-8508, Japan
Sports Genomics Laboratory, Department of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester M15 6BH, UK
Institute of Sport, Exercise and Health, University College London, London W1T 7HA, UK
Department of Physical Education, Plekhanov Russian University of Economics, 115093 Moscow, Russia
Laboratory of Molecular Genetics, Kazan State Medical University, 420012 Kazan, Russia
Author to whom correspondence should be addressed.
Academic Editors: Juan Del Coso and Italia Di Liegro
Genes 2022, 13(1), 25;
Received: 5 December 2021 / Revised: 16 December 2021 / Accepted: 22 December 2021 / Published: 23 December 2021
(This article belongs to the Special Issue Genetics and Genomics in Sport)
A recent case-control study identified 28 DNA polymorphisms associated with strength athlete status. However, studies of genotype-phenotype design are required to support those findings. The aim of the present study was to investigate both individually and in combination the association of 28 genetic markers with weightlifting performance in Russian athletes and to replicate the most significant findings in an independent cohort of Japanese athletes. Genomic DNA was collected from 53 elite Russian (31 men and 22 women, 23.3 ± 4.1 years) and 100 sub-elite Japanese (53 men and 47 women, 21.4 ± 4.2 years) weightlifters, and then genotyped using PCR or micro-array analysis. Out of 28 DNA polymorphisms, LRPPRC rs10186876 A, MMS22L rs9320823 T, MTHFR rs1801131 C, and PHACTR1 rs6905419 C alleles positively correlated (p < 0.05) with weightlifting performance (i.e., total lifts in snatch and clean and jerk in official competitions adjusted for sex and body mass) in Russian athletes. Next, using a polygenic approach, we found that carriers of a high (6–8) number of strength-related alleles had better competition results than carriers of a low (0–5) number of strength-related alleles (264.2 (14.7) vs. 239.1 (21.9) points; p = 0.009). These findings were replicated in the study of Japanese athletes. More specifically, Japanese carriers of a high number of strength-related alleles were stronger than carriers of a low number of strength-related alleles (212.9 (22.6) vs. 199.1 (17.2) points; p = 0.0016). In conclusion, we identified four common gene polymorphisms individually or in combination associated with weightlifting performance in athletes from East European and East Asian geographic ancestries. View Full-Text
Keywords: strength; weightlifter; athletes; polymorphism; genotype strength; weightlifter; athletes; polymorphism; genotype
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MDPI and ACS Style

Kikuchi, N.; Moreland, E.; Homma, H.; Semenova, E.A.; Saito, M.; Larin, A.K.; Kobatake, N.; Yusupov, R.A.; Okamoto, T.; Nakazato, K.; Williams, A.G.; Generozov, E.V.; Ahmetov, I.I. Genes and Weightlifting Performance. Genes 2022, 13, 25.

AMA Style

Kikuchi N, Moreland E, Homma H, Semenova EA, Saito M, Larin AK, Kobatake N, Yusupov RA, Okamoto T, Nakazato K, Williams AG, Generozov EV, Ahmetov II. Genes and Weightlifting Performance. Genes. 2022; 13(1):25.

Chicago/Turabian Style

Kikuchi, Naoki, Ethan Moreland, Hiroki Homma, Ekaterina A. Semenova, Mika Saito, Andrey K. Larin, Naoyuki Kobatake, Rinat A. Yusupov, Takanobu Okamoto, Koichi Nakazato, Alun G. Williams, Edward V. Generozov, and Ildus I. Ahmetov. 2022. "Genes and Weightlifting Performance" Genes 13, no. 1: 25.

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