A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™
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Forensic Genetics Research Group, Department of Forensic Sciences, Oslo University Hospital, 0372 Oslo, Norway
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Department of Forensic Medicine, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway
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Division of Biological Traces, Netherlands Forensic Institute, P.O. Box 24044, 2490 AA The Hague, The Netherlands
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Department of Statistics, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
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Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland 1142, New Zealand
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Forensic Science SA, GPO Box 2790, Adelaide, SA 5001, Australia
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School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Emiliano Giardina
Genes 2021, 12(10), 1559; https://doi.org/10.3390/genes12101559
Received: 22 July 2021
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Revised: 24 September 2021
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Accepted: 28 September 2021
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Published: 30 September 2021
(This article belongs to the Special Issue Advances in Forensic Genetics)
Probabilistic genotyping has become widespread. EuroForMix and DNAStatistX are both based upon maximum likelihood estimation using a γ model, whereas STRmix™ is a Bayesian approach that specifies prior distributions on the unknown model parameters. A general overview is provided of the historical development of probabilistic genotyping. Some general principles of interpretation are described, including: the application to investigative vs. evaluative reporting; detection of contamination events; inter and intra laboratory studies; numbers of contributors; proposition setting and validation of software and its performance. This is followed by details of the evolution, utility, practice and adoption of the software discussed.
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Keywords:
probabilistic genotyping; EuroForMix; DNAStatistX; STRmixTM
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MDPI and ACS Style
Gill, P.; Benschop, C.; Buckleton, J.; Bleka, Ø.; Taylor, D. A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™. Genes 2021, 12, 1559. https://doi.org/10.3390/genes12101559
AMA Style
Gill P, Benschop C, Buckleton J, Bleka Ø, Taylor D. A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™. Genes. 2021; 12(10):1559. https://doi.org/10.3390/genes12101559
Chicago/Turabian StyleGill, Peter, Corina Benschop, John Buckleton, Øyvind Bleka, and Duncan Taylor. 2021. "A Review of Probabilistic Genotyping Systems: EuroForMix, DNAStatistX and STRmix™" Genes 12, no. 10: 1559. https://doi.org/10.3390/genes12101559
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