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DEAD-Box RNA Helicases and Genome Stability

by 1,*,†, 1,2,† and 1,2,*
1
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Martin Dutertre
Genes 2021, 12(10), 1471; https://doi.org/10.3390/genes12101471
Received: 6 September 2021 / Revised: 19 September 2021 / Accepted: 20 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Reciprocal Links between RNA Metabolism and DNA Damage)
DEAD-box RNA helicases are important regulators of RNA metabolism and have been implicated in the development of cancer. Interestingly, these helicases constitute a major recurring family of RNA-binding proteins important for protecting the genome. Current studies have provided insight into the connection between genomic stability and several DEAD-box RNA helicase family proteins including DDX1, DDX3X, DDX5, DDX19, DDX21, DDX39B, and DDX41. For each helicase, we have reviewed evidence supporting their role in protecting the genome and their suggested mechanisms. Such helicases regulate the expression of factors promoting genomic stability, prevent DNA damage, and can participate directly in the response and repair of DNA damage. Finally, we summarized the pathological and therapeutic relationship between DEAD-box RNA helicases and cancer with respect to their novel role in genome stability. View Full-Text
Keywords: DEAD-box RNA helicases; genome stability; cancer DEAD-box RNA helicases; genome stability; cancer
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MDPI and ACS Style

Cargill, M.; Venkataraman, R.; Lee, S. DEAD-Box RNA Helicases and Genome Stability. Genes 2021, 12, 1471. https://doi.org/10.3390/genes12101471

AMA Style

Cargill M, Venkataraman R, Lee S. DEAD-Box RNA Helicases and Genome Stability. Genes. 2021; 12(10):1471. https://doi.org/10.3390/genes12101471

Chicago/Turabian Style

Cargill, Michael, Rasika Venkataraman, and Stanley Lee. 2021. "DEAD-Box RNA Helicases and Genome Stability" Genes 12, no. 10: 1471. https://doi.org/10.3390/genes12101471

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