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Open AccessFeature PaperArticle

Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia

1
Biomedical Research Institute INCLIVA, 46010 Valencia, Spain
2
Departament of Phisiology, University of Valencia, 46010 Valencia, Spain
3
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), 28029 Madrid, Spain
4
Hematology Department, Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Genes 2020, 11(6), 686; https://doi.org/10.3390/genes11060686
Received: 29 May 2020 / Revised: 14 June 2020 / Accepted: 19 June 2020 / Published: 23 June 2020
(This article belongs to the Section Human Genomics and Genetic Diseases)
Angiogenesis process contributes to the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) being the levels of VEGFA and bFGF higher in patients than in healthy controls. Our aim was to evaluate the implication of angiogenesis factors genetic variants in the predisposition to B-CLL and their association with clinical factors and survival. We performed a population-based case-control study in 224 Spanish B-CLL patients and 476 healthy randomly selected controls to evaluate susceptibility to developing B-CLL. Six polymorphisms were evaluated: rs1109324, rs1547651, rs3025039 (+936 C>T), rs833052 of the VEGFA gene, rs1449683 (c.233C>T) of the bFGF gene and (−710 C>T) of the VEGFR1 gene. The association between clinical parameters and patient outcome was analyzed. Carriers of the CT/TT variants of rs3025039 showed a significant protective effect against developing B-CLL. The CT/TT variants of rs1449683 show a tendency towards the development of the disease and the same variants associated significantly with higher genetic risk and with reduced disease free survival. Moreover, the association persisted in the early-stage disease subgroup. Our study provides evidence of the protective effect of the T/- rs3025039 VEGFA variant against B-CLL development and the association of CT/TT variants of the rs1449683 bFGF gene with genetic risk and an adverse survival. View Full-Text
Keywords: polymorphisms; chronic lymphocytic leukemia risk; vascular endothelial growth factor; fibroblast growth factor polymorphisms; chronic lymphocytic leukemia risk; vascular endothelial growth factor; fibroblast growth factor
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Ballester, S.; Pineda, B.; Rodrigues, P.; Tormo, E.; Terol, M.J.; Eroles, P. Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia. Genes 2020, 11, 686.

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