Finding MEMO—Emerging Evidence for MEMO1′s Function in Development and Disease
Abstract
:1. Introduction
2. PART I
2.1. MEMO1 in Receptor Signaling Pathways
2.1.1. Receptor Tyrosine Kinase (RTK) Signaling
2.1.2. Beyond RTK Signaling
2.2. MEMO1 in Cell Migration and Cytoskeletal Regulation
3. PART II
3.1. MEMO1′s Involvement in Reactive Oxygen Species Production and the Redox Environment
3.2. In Vivo Roles for MEMO1
3.2.1. Mineralization, Skeletogenesis and Mineral Homeostasis
3.2.2. Vascular Development
3.2.3. Longevity/Aging
3.2.4. Central Nervous System Development
4. PART III
4.1. MEMO1 in Human Disease
4.1.1. Preface: MEMO1 as an Essential Gene
4.1.2. Cancer
4.1.3. Neurodevelopmental or Neurological Disorders
4.1.4. Additional Potential Disorders
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
References
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A. Model System | B. RTK-Mediated Signaling and Beyond | C. Cytoskeleton | D. ROS | E. Other |
---|---|---|---|---|
In vitro cell lines | Marone 2004 [1] | Marone 2004 [1] | MacDonald 2014 [9] | |
Benseddik 2013 [7] | Benseddik 2013 [7] | |||
Meira 2009 [10] | Meira 2009 [10] | |||
Zaoui 2010 [12] | Zaoui 2010 [12] | |||
Zaoui 2008 [13] | Zaoui 2008 [13] | |||
Haenzi 2014 [15] | Bogoevska 2017 [37] | |||
Sorokin 2013 [17] | ||||
Jiang 2013 [20] | ||||
Frei 2016 [21] | ||||
Kondo 2014 [23] | ||||
Bogoevska 2017 [37] | ||||
S. cerevisiae | n/a | Schlatter 2012 [44] | Not studied | Viability/Longevity: Schlatter 2012 [44] |
C. elegans | Not studied | Not studied | Ewald 2017 [41] | Longevity: Ewald 2017 [41] |
M. musculus (Embryonic) | Not studied | Nakagawa 2019 [38] | Not studied | Viability: Kondo 2014 [23]; Van Otterloo 2016 [45] |
Vasculature: Kondo 2014 [23]; Van Otterloo 2016 [45] | ||||
Mineralization: Van Otterloo 2016 [45] | ||||
Neuronal Organization: Nakagawa 2019 [38]; Jereb 2018 [46] | ||||
M. musculus (Adult) | Not studied | Not studied | Moor 2018 [42] | Aging: Haenzi 2014 [15] |
Kidney/Serum: Haenzi 2014 [15]; Moor 2018 [42], 2016 [47], 2020 [48] | ||||
Mineralization: Moor 2018 [42], 2020 [48] | ||||
Structure/Binding | n/a | n/a | n/a | Burroughs 2019 [2]; Qiu 2008 [3]; Feracci 2011 [8]; Newkirk 2018 [11] |
A. Type of Cancer | B. # of pt. Samples | C. Assay Utilized | D. Expression Levels | E. Cellular Location (Patient Outcome) | Ref. |
---|---|---|---|---|---|
Breast-mixed | 407 | IHC | Protein significantly higher in breast cancer compared to controls | Cytosolic and/or nuclear (cytostolic = ↑ agressiveness, ↓ prognosis) | MacDonald [9] |
Colorectal | 60 | IHC | RNA and protein higher in colorectal cancer samples compared to controls | n/a (not reported) | Bogoevska [37] |
Pre-invasive DCIS | 8 | (RNA) microarray | RNA signifcantly upregulated in DCIS versus patient matched control tissue | n/a (not reported) | Hannafon [71] |
Pancreas-PDAC | 1 (established primary cell line) | (RNA/DNA) microarray | CNV’s and RNA signifcantly increased relative to control pancreatic tissue. | n/a (died 6 weeks after pancreaticoduodenectomy) | Kalinina [72] |
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Schotanus, M.D.; Van Otterloo, E. Finding MEMO—Emerging Evidence for MEMO1′s Function in Development and Disease. Genes 2020, 11, 1316. https://doi.org/10.3390/genes11111316
Schotanus MD, Van Otterloo E. Finding MEMO—Emerging Evidence for MEMO1′s Function in Development and Disease. Genes. 2020; 11(11):1316. https://doi.org/10.3390/genes11111316
Chicago/Turabian StyleSchotanus, Michaela D., and Eric Van Otterloo. 2020. "Finding MEMO—Emerging Evidence for MEMO1′s Function in Development and Disease" Genes 11, no. 11: 1316. https://doi.org/10.3390/genes11111316