Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data
2.2. Quantifying Yeast Growth Plasticity
2.3. Heritability Estimation
2.4. Mapping Alleles Underlying Variation in Phenotypic Plasticity
2.5. Estimating the Significance Threshold for the Association Analyses
2.6. Connecting Plasticity QTL to Previously Detected Epistatic Networks
3. Results
3.1. Heritable Variation in Yeast Growth Plasticity in Response to Chemical Stress
3.2. Mapping Alleles Contributing to the Variation in Growth Plasticity
3.3. Many Plasticity QTLs are Hub Loci in Previously Detected Epistatic Networks
3.4. A Known Epistatic Growth Hub QTL Affecting Specific and Overall Plasticity
4. Discussion
4.1. Quantification of the Phenotypic Plasticity
4.2. The Role of QTL–QTL and QTL–Environment Interactions in Phenotype Plasticity
4.3. Relationship to Earlier Studies Evaluating the Role of G-by-G-by-E Interactions on Growth Variation in Individual Environments
4.4. Candidate Genes Contributing to Variation in Phenotype Plasticity
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Zan, Y.; Carlborg, Ö. Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes. Genes 2020, 11, 1279. https://doi.org/10.3390/genes11111279
Zan Y, Carlborg Ö. Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes. Genes. 2020; 11(11):1279. https://doi.org/10.3390/genes11111279
Chicago/Turabian StyleZan, Yanjun, and Örjan Carlborg. 2020. "Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes" Genes 11, no. 11: 1279. https://doi.org/10.3390/genes11111279