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A Label-Free Assay for Aminoacylation of tRNA
Review

Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases

Faculty of Biology, Technion––Israel Institute of Technology, Haifa 32000, Israel
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Genes 2020, 11(10), 1185; https://doi.org/10.3390/genes11101185
Received: 9 September 2020 / Revised: 5 October 2020 / Accepted: 8 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue tRNAs in Biology)
Mitochondria contain a complete translation machinery that is used to translate its internally transcribed mRNAs. This machinery uses a distinct set of tRNAs that are charged with cognate amino acids inside the organelle. Interestingly, charging is executed by aminoacyl tRNA synthetases (aaRS) that are encoded by the nuclear genome, translated in the cytosol, and need to be imported into the mitochondria. Here, we review import mechanisms of these enzymes with emphasis on those that are localized to both mitochondria and cytosol. Furthermore, we describe RNA recognition features of these enzymes and their interaction with tRNA and non-tRNA molecules. The dual localization of mitochondria-destined aaRSs and their association with various RNA types impose diverse impacts on cellular physiology. Yet, the breadth and significance of these functions are not fully resolved. We highlight here possibilities for future explorations. View Full-Text
Keywords: aminoacyl tRNA synthetase; mitochondria; tRNA; mitochondria import; mitochondria targeting signal; RNA recognition; translation aminoacyl tRNA synthetase; mitochondria; tRNA; mitochondria import; mitochondria targeting signal; RNA recognition; translation
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MDPI and ACS Style

Garin, S.; Levi, O.; Cohen, B.; Golani-Armon, A.; Arava, Y.S. Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases. Genes 2020, 11, 1185. https://doi.org/10.3390/genes11101185

AMA Style

Garin S, Levi O, Cohen B, Golani-Armon A, Arava YS. Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases. Genes. 2020; 11(10):1185. https://doi.org/10.3390/genes11101185

Chicago/Turabian Style

Garin, Shahar, Ofri Levi, Bar Cohen, Adi Golani-Armon, and Yoav S. Arava 2020. "Localization and RNA Binding of Mitochondrial Aminoacyl tRNA Synthetases" Genes 11, no. 10: 1185. https://doi.org/10.3390/genes11101185

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