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Volume 11
Issue 1
10.3390/genes11010079
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Review

Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes

by
Hannah M. Hylton
1,†,
Bailey E. Lucas
2,† and
Ruben C. Petreaca
3,*
1
Biology Program, The Ohio State University, Marion, OH 43302, USA
2
The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
3
Department of Molecular Genetics, The Ohio State University, Marion, OH 43302, USA
*
Author to whom correspondence should be addressed.
†
Denotes equal contribution.
Genes 2020, 11(1), 79; https://doi.org/10.3390/genes11010079
Submission received: 20 December 2019 / Revised: 7 January 2020 / Accepted: 7 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Recent Advances in Molecular Genetics Technologies: A Themed Issue Honouring Professor Werner Arber on the Occasion of his 90th Birthday)
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Abstract

The fission yeast—Schizosaccharomyces pombe—has emerged as a powerful tractable system for studying DNA damage repair. Over the last few decades, several powerful in vivo genetic assays have been developed to study outcomes of mitotic recombination, the major repair mechanism of DNA double strand breaks and stalled or collapsed DNA replication forks. These assays have significantly increased our understanding of the molecular mechanisms underlying the DNA damage response pathways. Here, we review the assays that have been developed in fission yeast to study mitotic recombination.
Keywords: mitotic recombination; DNA replication; double strand break (DSB); chromosomal rearrangements mitotic recombination; DNA replication; double strand break (DSB); chromosomal rearrangements

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MDPI and ACS Style

Hylton, H.M.; Lucas, B.E.; Petreaca, R.C. Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes. Genes 2020, 11, 79. https://doi.org/10.3390/genes11010079

AMA Style

Hylton HM, Lucas BE, Petreaca RC. Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes. Genes. 2020; 11(1):79. https://doi.org/10.3390/genes11010079

Chicago/Turabian Style

Hylton, Hannah M., Bailey E. Lucas, and Ruben C. Petreaca. 2020. "Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes" Genes 11, no. 1: 79. https://doi.org/10.3390/genes11010079

APA Style

Hylton, H. M., Lucas, B. E., & Petreaca, R. C. (2020). Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes. Genes, 11(1), 79. https://doi.org/10.3390/genes11010079

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