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Genome Analysis of Hypomyces perniciosus, the Causal Agent of Wet Bubble Disease of Button Mushroom (Agaricus bisporus)

1
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China
2
International Cooperation Research Center of China for New Germplasm and Breeding of Edible Mushrooms, Jilin Agricultural University, Changchun 130118, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2019, 10(6), 417; https://doi.org/10.3390/genes10060417
Received: 4 April 2019 / Revised: 17 May 2019 / Accepted: 27 May 2019 / Published: 29 May 2019
(This article belongs to the Section Microbial Genetics and Genomics)
The mycoparasitic fungus Hypomyces perniciosus causes wet bubble disease of mushrooms, particularly Agaricus bisporus. The genome of a highly virulent strain of H. perniciosus HP10 was sequenced and compared to three other fungi from the order Hypocreales that cause disease on A. bisporus. H. perniciosus genome is ~44 Mb, encodes 10,077 genes and enriched with transposable elements up to 25.3%. Phylogenetic analysis revealed that H. perniciosus is closely related to Cladobotryum protrusum and diverged from their common ancestor ~156.7 million years ago. H. perniciosus has few secreted proteins compared to C. protrusum and Trichoderma virens, but significantly expanded protein families of transporters, protein kinases, CAZymes (GH 18), peptidases, cytochrome P450, and SMs that are essential for mycoparasitism and adaptation to harsh environments. This study provides insights into H. perniciosus evolution and pathogenesis and will contribute to the development of effective disease management strategies to control wet bubble disease. View Full-Text
Keywords: Hypomyces perniciosus; genome sequence; Agaricus bisporus; wet bubble disease; CAZymes; cytochrome P450 enzymes; secondary metabolites Hypomyces perniciosus; genome sequence; Agaricus bisporus; wet bubble disease; CAZymes; cytochrome P450 enzymes; secondary metabolites
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MDPI and ACS Style

Li, D.; Sossah, F.L.; Sun, L.; Fu, Y.; Li, Y. Genome Analysis of Hypomyces perniciosus, the Causal Agent of Wet Bubble Disease of Button Mushroom (Agaricus bisporus). Genes 2019, 10, 417.

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