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Article

Comprehensive Expression Profiling Analysis of Pituitary Indicates that circRNA Participates in the Regulation of Sheep Estrus

1
College of Life Sciences, Shihezi University, Shihezi 832003, Xinjiang, China
2
College of Animal Science and Technology, Shihezi University, Shihezi 832003, Xinjiang, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2019, 10(2), 90; https://doi.org/10.3390/genes10020090
Received: 3 December 2018 / Revised: 23 January 2019 / Accepted: 23 January 2019 / Published: 28 January 2019
(This article belongs to the Section Animal Genetics and Genomics)
The pituitary gland is the most important endocrine organ that mainly regulates animal estrus by controlling the hormones synthesis. There is a significant difference between the estrus state and anestrus state of sheep pituitary system. Here, we studied the circular RNA (circRNA) expression profiles of the anterior pituitary of estrus and anestrus sheep using RNA-seq technology. Through this study, we identified a total of 12,468 circRNAs and 9231 differentially expressed circRNAs in the estrus and anestrus pituitary system of sheep. We analyzed some differentially expressed circRNAs by reverse transcription quantitative-PCR (RT-qPCR), and some circRNAs were demonstrated using RNase-R+ resistance experiments. CircRNAs involving the regulation of estrus-related terms and pathways are enriched by using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. In addition, we also predicted partial microRNA-circRNA interaction network for circRNAs that regulate sheep estrus. Overall, this study explored a potential substantial role played by circRNAs involved in pituitary regulation on sheep estrus and proposed new questions for further study. View Full-Text
Keywords: sheep; circRNAs; estrus; anestrus; anterior pituitary sheep; circRNAs; estrus; anestrus; anterior pituitary
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MDPI and ACS Style

Li, X.; Li, C.; Wei, J.; Ni, W.; Xu, Y.; Yao, R.; Zhang, M.; Li, H.; Liu, L.; Dang, H.; Hazi, W.; Hu, S. Comprehensive Expression Profiling Analysis of Pituitary Indicates that circRNA Participates in the Regulation of Sheep Estrus. Genes 2019, 10, 90. https://doi.org/10.3390/genes10020090

AMA Style

Li X, Li C, Wei J, Ni W, Xu Y, Yao R, Zhang M, Li H, Liu L, Dang H, Hazi W, Hu S. Comprehensive Expression Profiling Analysis of Pituitary Indicates that circRNA Participates in the Regulation of Sheep Estrus. Genes. 2019; 10(2):90. https://doi.org/10.3390/genes10020090

Chicago/Turabian Style

Li, Xiaoyue; Li, Cunyuan; Wei, Junchang; Ni, Wei; Xu, Yueren; Yao, Rui; Zhang, Mengdan; Li, Huixiang; Liu, Li; Dang, Hanli; Hazi, Wureli; Hu, Shengwei. 2019. "Comprehensive Expression Profiling Analysis of Pituitary Indicates that circRNA Participates in the Regulation of Sheep Estrus" Genes 10, no. 2: 90. https://doi.org/10.3390/genes10020090

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