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Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

1
Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10065, USA
2
Nuclear Medicine Department, College of Medicine, University of Ibadan, Ibadan 200222, Nigeria
3
Department of Surgery, Urology division, College of Medicine, University of Ibadan, Ibadan 200222, Nigeria
4
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(12), 964; https://doi.org/10.3390/genes10120964
Received: 3 October 2019 / Revised: 15 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Associations Between Non-Coding RNA and Diseases)
Prostate cancer (PCa) is the most common non-cutaneous cancer and second leading cause of cancer-related death for men in the United States. The nonprotein coding gene locus plasmacytoma variant translocation 1 (PVT1) is located at 8q24 and is dysregulated in different cancers. PVT1 gives rise to several alternatively spliced transcripts and microRNAs. There are at least twelve exons of PVT1, which make separate transcripts, and likely have different functions. Here, we demonstrate that PVT1 exon 9 is significantly overexpressed in PCa tissues in comparison to normal prostate tissues. Both transient and stable overexpression of PVT1 exon 9 significantly induced greater prostate epithelial cell migration, as well as increased proliferation and corresponding proliferating cell nuclear antigen (PCNA) expression. Notably, implantation into mice of a non-tumorigenic prostate epithelial cell line stably overexpressing PVT1 exon 9 resulted in the formation of malignant tumors. Furthermore, PVT1 exon 9 overexpression significantly induced castration resistance. Consequently, PVT1 exon 9 expression is important for PCa initiation and progression, and holds promise as a therapeutic target in PCa.
Keywords: PVT1 exon 9; prostate cancer; malignant transformation; castration resistance PVT1 exon 9; prostate cancer; malignant transformation; castration resistance
MDPI and ACS Style

Pal, G.; Huaman, J.; Levine, F.; Orunmuyi, A.; Olapade-Olaopa, E.O.; Onagoruwa, O.T.; Ogunwobi, O.O. Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells. Genes 2019, 10, 964.

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