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Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Genes 2019, 10(11), 859; https://doi.org/10.3390/genes10110859
Received: 10 October 2019 / Revised: 25 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
(This article belongs to the Special Issue DNA Topoisomerases in Biology and Medicine)
Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly useful for their ability to disentangle newly-replicated sister chromosomes. Growing lines of evidence indicate that eukaryotic topoisomerase II (topo II) activity is monitored and regulated throughout the cell cycle. Here, we discuss the various roles of topo II throughout the cell cycle, as well as mechanisms that have been found to govern and/or respond to topo II function and dysfunction. Knowledge of how topo II activity is controlled during cell cycle progression is important for understanding how its misregulation can contribute to genetic instability and how modulatory pathways may be exploited to advance chemotherapeutic development. View Full-Text
Keywords: topoisomerase II; cell cycle; mitosis; DNA replication; decatenation; cell cycle checkpoint; cancer topoisomerase II; cell cycle; mitosis; DNA replication; decatenation; cell cycle checkpoint; cancer
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Lee, J.H.; Berger, J.M. Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II. Genes 2019, 10, 859.

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