Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Raw Data and Procession
2.2. Gene Co-Expression Network and Modules
2.3. Hub Gene Identification and Validation
3. Results
3.1. Gene Expression Data
3.2. Clinically Significant Modules
3.3. Hub Genes
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Genes Symbol | Full Name | R | P-Value |
---|---|---|---|
ADAMTS19 | Disintegrin and Metalloprotease Domain (ADAM) Metallopeptidase with Thrombospondin Type 1 Motif 19 | 0.96 | 6.68 × 10−40 |
KCNT2 | Potassium Sodium-Activated Channel Subfamily T Member 2 | 0.95 | 1.50 × 10−39 |
CASP12 | Caspase 12 | 0.94 | 4.48 × 10−39 |
ADD3-AS1 | Adducin 3 Antisense RNA 1 | 0.93 | 2.78 × 10−33 |
DISP1 | Dispatched RND Transporter Family Member 1 | 0.93 | 1.57 × 10−32 |
PTN | Pleiotrophin | 0.92 | 8.81 × 10−32 |
CNTN1 | Contactin 1 | 0.92 | 1.94 × 10−31 |
TMEM108 | Transmembrane Protein 108 | 0.92 | 1.61 × 10−30 |
HPSE2 | Heparanase 2 | 0.92 | 2.14 × 10−30 |
GRIA1 | Glutamate Ionotropic Receptor AMPA Type Subunit 1 | 0.91 | 6.86 × 10−30 |
HKDC1 | Hexokinase Domain Containing 1 | 0.91 | 1.58 × 10−29 |
STK26 | Serine/Threonine Kinase 26 | 0.91 | 1.36 × 10−28 |
CYP39A1 | Cytochrome P450 Family 39 Subfamily A Member 1 | 0.90 | 3.26 × 10−28 |
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Yang, L.; Xu, Y.; Yan, Y.; Luo, P.; Chen, S.; Zheng, B.; Yan, W.; Chen, Y.; Wang, C. Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis. Genes 2019, 10, 747. https://doi.org/10.3390/genes10100747
Yang L, Xu Y, Yan Y, Luo P, Chen S, Zheng B, Yan W, Chen Y, Wang C. Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis. Genes. 2019; 10(10):747. https://doi.org/10.3390/genes10100747
Chicago/Turabian StyleYang, Lingge, Yu Xu, Yan Yan, Peng Luo, Shiqi Chen, Biqiang Zheng, Wangjun Yan, Yong Chen, and Chunmeng Wang. 2019. "Common Nevus and Skin Cutaneous Melanoma: Prognostic Genes Identified by Gene Co-Expression Network Analysis" Genes 10, no. 10: 747. https://doi.org/10.3390/genes10100747