The Role of Molecular Testing for the Indeterminate Thyroid FNA
1
Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, 00168 Rome, Italy
2
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
3
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(10), 736; https://doi.org/10.3390/genes10100736
Received: 1 August 2019 / Revised: 13 September 2019 / Accepted: 18 September 2019 / Published: 23 September 2019
(This article belongs to the Special Issue Thyroid Cancer: Genetics and Targeted Therapies)
Thyroid nodules are common in the adult population where a majority are benign and only 4.0% to 6.5% are malignant. Fine needle aspiration (FNA) is a key method used in the early stages to evaluate and triage patients with thyroid nodules. While a definitive cytological diagnosis is provided in more than 70–75% of all thyroid FNA cases, the group of indeterminate lesions offers a challenge in terms of interpretation and clinical management. Molecular testing platforms have been developed, are recognized as an option by the 2015 American Thyroid Association Guidelines, and are frequently used in conjunction with FNA as an integral part of the cytologic evaluation. In this review, the utility of molecular testing options for nodules assigned to the group of indeterminate thyroid FNAs is described.
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Keywords:
fine needle aspiration; cytology; thyroid cancers; molecular testing; personalized medicine
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MDPI and ACS Style
Rossi, E.D.; Pantanowitz, L.; Faquin, W.C. The Role of Molecular Testing for the Indeterminate Thyroid FNA. Genes 2019, 10, 736. https://doi.org/10.3390/genes10100736
AMA Style
Rossi ED, Pantanowitz L, Faquin WC. The Role of Molecular Testing for the Indeterminate Thyroid FNA. Genes. 2019; 10(10):736. https://doi.org/10.3390/genes10100736
Chicago/Turabian StyleRossi, Esther D.; Pantanowitz, Liron; Faquin, William C. 2019. "The Role of Molecular Testing for the Indeterminate Thyroid FNA" Genes 10, no. 10: 736. https://doi.org/10.3390/genes10100736
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