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Heavy Metal Resistance Determinants of the Foodborne Pathogen Listeria monocytogenes

by Cameron Parsons 1,*,†, Sangmi Lee 2,† and Sophia Kathariou 1
1
Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695-7624, USA
2
Seoul National University, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
Authors contributed equally to this manuscript.
Genes 2019, 10(1), 11; https://doi.org/10.3390/genes10010011
Received: 16 November 2016 / Revised: 17 December 2018 / Accepted: 18 December 2018 / Published: 24 December 2018
(This article belongs to the Special Issue Genomics of Bacterial Metal Resistance)
Listeria monocytogenes is ubiquitous in the environment and causes the disease listeriosis. Metal homeostasis is one of the key processes utilized by L. monocytogenes in its role as either a saprophyte or pathogen. In the environment, as well as within an animal host, L. monocytogenes needs to both acquire essential metals and mitigate toxic levels of metals. While the mechanisms associated with acquisition and detoxification of essential metals such as copper, iron, and zinc have been extensively studied and recently reviewed, a review of the mechanisms associated with non-essential heavy metals such as arsenic and cadmium is lacking. Resistance to both cadmium and arsenic is frequently encountered in L. monocytogenes, including isolates from human listeriosis. In addition, a growing body of work indicates the association of these determinants with other cellular functions such as virulence, suggesting the importance of further study in this area. View Full-Text
Keywords: Listeria monocytogenes; heavy metal resistance; mobile genetic element; cadmium; arsenic Listeria monocytogenes; heavy metal resistance; mobile genetic element; cadmium; arsenic
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Parsons, C.; Lee, S.; Kathariou, S. Heavy Metal Resistance Determinants of the Foodborne Pathogen Listeria monocytogenes. Genes 2019, 10, 11.

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