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Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series

1
Plastic, Aesthetic Hand- & Reconstructive Surgery, Marien Hospital Soest, 59494 Soest, Germany
2
Medical Affairs, Human Med AG, 19061 Schwerin, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(9), 2096; https://doi.org/10.3390/cells9092096
Received: 17 August 2020 / Revised: 11 September 2020 / Accepted: 11 September 2020 / Published: 14 September 2020
(This article belongs to the Collection Research on Adipose Stem Cells)
Osteoarthritis (OA) is the most common form of arthritis of the joints. The stromal vascular fraction (SVF) is a regenerative cell population that can be isolated from adipose tissue. It is the immunomodulatory properties of the stromal vascular fraction that make it a promising candidate for the regenerative treatment of OA. Patients with grade 3 and 4 osteoarthritis were treated with the stromal vascular fraction with and without platelet-rich plasma (PRP) and followed up on their Knee Injury and Osteoarthritis Outcome Score (KOOS) score for 12 months, with MRI and subjective evaluation of the procedure. Magnetic resonance imaging (MRI) revealed a widening of the joint space, a restructuring of the cartilage, and an alleviation of effusions in the treated joints. In three of the four treatment groups, a substantial improvement of the KOOS scores was documented at the 12-month follow-up time point. According to the subjective evaluation, 67% of the patients were satisfied or very satisfied with the procedure and would recommend it to others. No serious adverse events or unwanted side effects related to the SVF treatment were observed or reported. Prior to an invasive artificial joint replacement, the treatment of arthritic knee joints with the intraarticular injection of autologous adipose tissue-derived SVF should be considered a regenerative treatment option. View Full-Text
Keywords: stromal vascular fraction (SVF); therapeutics; osteoarthritis (OA); adipose tissue-derived stem/stromal cells (ASCs); Q-graft® stromal vascular fraction (SVF); therapeutics; osteoarthritis (OA); adipose tissue-derived stem/stromal cells (ASCs); Q-graft®
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MDPI and ACS Style

Simunec, D.; Salari, H.; Meyer, J. Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series. Cells 2020, 9, 2096. https://doi.org/10.3390/cells9092096

AMA Style

Simunec D, Salari H, Meyer J. Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series. Cells. 2020; 9(9):2096. https://doi.org/10.3390/cells9092096

Chicago/Turabian Style

Simunec, Denis, Honey Salari, and Juliane Meyer. 2020. "Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series" Cells 9, no. 9: 2096. https://doi.org/10.3390/cells9092096

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