ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart
Abstract
:1. Protein Secretion in the Heart
2. ER Stress in the Heart
2.1. Cardiac Proteostasis at the ER
2.2. ER Stress and Heart Disease
3. Protein Secretion during ER Stress
4. Secretion of Ca2+-Binding ER Chaperones
4.1. Secretion during Ca2+-Mediated ER Stress
4.2. Extracellular Functions of ER Chaperones in the Cardiovascular System
4.3. Extracellular Functions of ER Chaperones in Non-Cardiovascular Cells and Tissues
4.3.1. 78 kDa Glucose-Regulated Protein (GRP78; Binding Immunoglobulin Protein)
4.3.2. Other Ca2+-Binding ER Chaperones: Calreticulin, 94 kDa Glucose-Regulated Protein (GRP94; Endoplasmin; Gp96), MANF
5. Secretion of Other Proteins during ER Stress
5.1. Other Cardiokines
5.2. ERdj3 (Endoplasmic Reticulum DNA J Domain-Containing Protein 3; DnaJ Homolog Subfamily B Member 11)
5.3. Angiogenin
6. Conclusions and Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Meyer, B.A.; Doroudgar, S. ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart. Cells 2020, 9, 2066. https://doi.org/10.3390/cells9092066
Meyer BA, Doroudgar S. ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart. Cells. 2020; 9(9):2066. https://doi.org/10.3390/cells9092066
Chicago/Turabian StyleMeyer, Bianca A., and Shirin Doroudgar. 2020. "ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart" Cells 9, no. 9: 2066. https://doi.org/10.3390/cells9092066