Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies
Abstract
:1. Introduction
2. Microvesicles and Apoptotic Bodies
3. Exosomes: Biogenesis and Release
4. Senescence and Its Effect on Stem Cell Biology, Transplantation, and Function
5. Role of Extracellular Vesicles in Age-Related Diseases
6. Neurodegenerative Disorders
7. Cardiovascular Disorders
8. Diabetes
9. Other Age-Related Pathologies
10. Exosome Cargo in Senescence
11. EVs as Potential Diagnostic Markers and Therapeutic Tools for Age-Related Diseases
12. Role of Exosomes in COVID-19 Patients
13. Future Perspectives and Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Exosomes from Young Individual | Exosomes from Aged Individual |
---|---|
Normal levels of EV | Increased EV secretion |
Exosomes do not have an adverse effect on tissue microenvironment | Exosomes from senescent cells are detrimental to the tissue microenvironment |
Exosomal cargo do not result in any pathological changes | Exosomal cargo can mediate/accelerate pathological changes |
Normal expression of miRNAs and proteins | Differential expression of miRNAs and proteins could act as biomarkers for diagnosis of age-related pathologies |
Exosomal miRNA | Derived From | Function | Reference |
---|---|---|---|
miR-96, miR-182, miR-183 | Bone marrow | Increase senescence in bone marrow cells | [101] |
miR-24-3p | Saliva | Inflammatory cytokine and chemokine gene regulation | [102] |
miR-151a-3p, miR-181a-5p, miR-1258, miR-29b, miR-106b, miR-130b. miR-142-5p, miR-340 | Serum | Down-regulated with aging | [104] |
miR-92a, miR-222, miR-192 | Serum | Up-regulated with aging | [105] |
miR-15 | Urine | Differentially expressed in diabetic nephropathy | [106] |
miR-15a-3p | Blood | Up-regulated in diabetic patients | [107] |
miR-125a-5p, miR-23a-3p, miR-375 | Blood | Differentially expressed in Alzhemier’s Disease | [110] |
hsa-miR-203-3p, hsa-miR-4482-3p,hsa-miR-44366b-3p | COVID-19 patients | Target S protein involved in viral replication | [112] |
hsa-miR-190a-5p | COVID-19 patients | Target ORF6 involved in immune suppression | [112] |
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Saheera, S.; Potnuri, A.G.; Krishnamurthy, P. Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies. Cells 2020, 9, 1974. https://doi.org/10.3390/cells9091974
Saheera S, Potnuri AG, Krishnamurthy P. Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies. Cells. 2020; 9(9):1974. https://doi.org/10.3390/cells9091974
Chicago/Turabian StyleSaheera, Sherin, Ajay Godwin Potnuri, and Prasanna Krishnamurthy. 2020. "Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies" Cells 9, no. 9: 1974. https://doi.org/10.3390/cells9091974