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Hyaluronic Acid: Redefining Its Role

Faculty of Medicine, University of Padova, 35121 Padova, Italy
Clinic of Plastic and Reconstructive Surgery, University of Padova, 35128 Padova, Italy
Department of Cardiac, Thoracic and Vascular Sciences, Angiology Unit, University of Padova, 35128 Padova, Italy
Department of Molecular Medicine, Histology unit, University of Padova, 35121 Padova, Italy
Author to whom correspondence should be addressed.
Cells 2020, 9(7), 1743;
Received: 31 May 2020 / Revised: 17 July 2020 / Accepted: 19 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Hyaluronic Acid: Basic and Clinical Aspects)
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has promoted new research impetus for biologists and, the clinical interest in several fields of medicine, such as ophthalmology, articular pathologies, cutaneous repair, skin remodeling, vascular prosthesis, adipose tissue engineering, nerve reconstruction and cancer therapy. In addition, the great potential of HA in medicine has stimulated the interest of pharmaceutical companies which, by means of new technologies can produce HA and several new derivatives in order to increase both the residence time in a variety of human tissues and the anti-inflammatory properties. Minor chemical modifications of the molecule, such as the esterification with benzyl alcohol (Hyaff-11® biomaterials), have made possible the production of water-insoluble polymers that have been manufactured in various forms: membranes, gauzes, nonwoven meshes, gels, tubes. All these biomaterials are used as wound-covering, anti-adhesive devices and as scaffolds for tissue engineering, such as epidermis, dermis, micro-vascularized skin, cartilage and bone. In this review, the essential biological functions of HA and the applications of its derivatives for pharmaceutical and tissue regeneration purposes are reviewed. View Full-Text
Keywords: hyaluronic acid (HA), HA receptors; osteoarthritis; tissue-engineering hyaluronic acid (HA), HA receptors; osteoarthritis; tissue-engineering
MDPI and ACS Style

Abatangelo, G.; Vindigni, V.; Avruscio, G.; Pandis, L.; Brun, P. Hyaluronic Acid: Redefining Its Role. Cells 2020, 9, 1743.

AMA Style

Abatangelo G, Vindigni V, Avruscio G, Pandis L, Brun P. Hyaluronic Acid: Redefining Its Role. Cells. 2020; 9(7):1743.

Chicago/Turabian Style

Abatangelo, G., V. Vindigni, G. Avruscio, L. Pandis, and P. Brun. 2020. "Hyaluronic Acid: Redefining Its Role" Cells 9, no. 7: 1743.

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