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Open AccessFeature PaperReview

GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness

Department of Molecular Physiology and Neurobiology, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland
Authors to whom correspondence should be addressed.
Cells 2020, 9(3), 727;
Received: 4 February 2020 / Revised: 12 March 2020 / Accepted: 14 March 2020 / Published: 16 March 2020
Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is suggested to be engaged in the pathogenesis of major depressive disorder, and to be a target and/or modifier of anti-depressants’ action. In this review, we discuss abnormalities in the activity of GSK3β and its upstream regulators in different brain regions during depressive episodes. Additionally, putative role(s) of GSK3β in the pathogenesis of depression and the influence of anti-depressants on GSK3β activity are discussed. View Full-Text
Keywords: GSK3β; MDD; depression; anti-depressants; AKT; BDNF; neuroprotection GSK3β; MDD; depression; anti-depressants; AKT; BDNF; neuroprotection
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MDPI and ACS Style

Duda, P.; Hajka, D.; Wójcicka, O.; Rakus, D.; Gizak, A. GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness. Cells 2020, 9, 727.

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