Next Article in Journal
SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts
Next Article in Special Issue
GSK3: A Kinase Balancing Promotion and Resolution of Inflammation
Previous Article in Journal
Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles
Previous Article in Special Issue
A Unique GSK-3β inhibitor B10 Has a Direct Effect on Aβ, Targets Tau and Metal Dyshomeostasis, and Promotes Neuronal Neurite Outgrowth
Open AccessFeature PaperReview

GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness

Department of Molecular Physiology and Neurobiology, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(3), 727; https://doi.org/10.3390/cells9030727
Received: 4 February 2020 / Revised: 12 March 2020 / Accepted: 14 March 2020 / Published: 16 March 2020
Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is suggested to be engaged in the pathogenesis of major depressive disorder, and to be a target and/or modifier of anti-depressants’ action. In this review, we discuss abnormalities in the activity of GSK3β and its upstream regulators in different brain regions during depressive episodes. Additionally, putative role(s) of GSK3β in the pathogenesis of depression and the influence of anti-depressants on GSK3β activity are discussed. View Full-Text
Keywords: GSK3β; MDD; depression; anti-depressants; AKT; BDNF; neuroprotection GSK3β; MDD; depression; anti-depressants; AKT; BDNF; neuroprotection
Show Figures

Figure 1

MDPI and ACS Style

Duda, P.; Hajka, D.; Wójcicka, O.; Rakus, D.; Gizak, A. GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness. Cells 2020, 9, 727.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop