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Infectious Diseases and the Lymphoid Extracellular Matrix Remodeling: A Focus on Conduit System

Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro-RJ 21040-360, Brazil
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Cells 2020, 9(3), 725; https://doi.org/10.3390/cells9030725
Received: 31 January 2020 / Revised: 9 March 2020 / Accepted: 11 March 2020 / Published: 16 March 2020
(This article belongs to the Special Issue Extracellular Matrix Remodeling 2019)
The conduit system was described in lymphoid organs as a tubular and reticular set of structures compounded by collagen, laminin, perlecan, and heparin sulfate proteoglycan wrapped by reticular fibroblasts. This tubular system is capable of rapidly transport small molecules such as viruses, antigens, chemokines, cytokines, and immunoglobulins through lymphoid organs. This structure plays an important role in guiding the cells to their particular niches, therefore participating in cell cooperation, antigen presentation, and cellular activation. The remodeling of conduits has been described in chronic inflammation and infectious diseases to improve the transport of antigens to specific T and B cells in lymphoid tissue. However, malnutrition and infectious agents may induce extracellular matrix remodeling directly or indirectly, leading to the microarchitecture disorganization of secondary lymphoid organs and their conduit system. In this process, the fibers and cells that compound the conduit system may also be altered, which affects the development of a specific immune response. This review aims to discuss the extracellular matrix remodeling during infectious diseases with an emphasis on the alterations of molecules from the conduit system, which damages the cellular and molecular transit in secondary lymphoid organs compromising the immune response. View Full-Text
Keywords: extracellular matrix; conduit system; remodeling; infectious diseases; spleen; lymph node extracellular matrix; conduit system; remodeling; infectious diseases; spleen; lymph node
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Morgado, F.N.; da Silva, A.V.A.; Porrozzi, R. Infectious Diseases and the Lymphoid Extracellular Matrix Remodeling: A Focus on Conduit System. Cells 2020, 9, 725.

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