Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery
Abstract
:1. Protein Translation in Bacteria and Eukaryotes
2. Forces Generated at the Level of the Ribosomal Machinery
2.1. EF-G and the Ribosome Acts as a Molecular Ratchet System to Drive mRNA–tRNA Translocation
2.2. mRNA Secondary Structures as Mechanical Barriers to the Ribosome
2.3. Forces on the Nascent Polypeptide Generated during co-Translation Folding
3. Cell Mechanics and the Protein Translation Machinery
4. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Simpson, L.J.; Tzima, E.; Reader, J.S. Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery. Cells 2020, 9, 650. https://doi.org/10.3390/cells9030650
Simpson LJ, Tzima E, Reader JS. Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery. Cells. 2020; 9(3):650. https://doi.org/10.3390/cells9030650
Chicago/Turabian StyleSimpson, Lisa J., Ellie Tzima, and John S. Reader. 2020. "Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery" Cells 9, no. 3: 650. https://doi.org/10.3390/cells9030650