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Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, SP 14040-903, Brazil
Department of Maternal and Child Nursing and Public Health, School of Nurse of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, SP 14040-902, Brazil
Authors to whom correspondence should be addressed.
Cells 2020, 9(3), 628;
Received: 3 January 2020 / Revised: 6 February 2020 / Accepted: 7 February 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Mitochondria, Metabolism and Cancer)
Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was to evaluate the ability of exercise to modulate tumor growth and energy metabolism in an experimental TNBC model. Female BALB/c mice were sedentary or trained for 12 weeks and inoculated with 1 × 104 4T1 cells in the eighth week. Analyzes of macronutrient oxidation, mitochondrial respiration, and expression of genes related to cell metabolism were performed. The results showed that the trained group had a smaller tumor mass and the mitochondria in the tumors presented lower respiratory rates in the state of maximum electron transport capacity. Additionally, the tumors of the exercised group showed a higher expression of genes related to tumor suppressors, while the genes linked with cellular growth were similar between groups. Furthermore, the training modulated the corporal macronutrient oxidation to almost exclusive carbohydrate oxidation, while the sedentary condition metabolized both carbohydrate and lipids. Therefore, the exercise reduced tumor growth, with an impact on mitochondrial and macronutrient metabolism. Our results shed light on the understanding of the antitumorigenic effects of physical exercise, particularly regarding the metabolic transformations in TNBC. View Full-Text
Keywords: mitochondria; OXPHOS; training; TNBC mitochondria; OXPHOS; training; TNBC
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MDPI and ACS Style

Vulczak, A.; Souza, A.d.O.; Ferrari, G.D.; Azzolini, A.E.C.S.; Pereira-da-Silva, G.; Alberici, L.C. Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer. Cells 2020, 9, 628.

AMA Style

Vulczak A, Souza AdO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC. Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer. Cells. 2020; 9(3):628.

Chicago/Turabian Style

Vulczak, Anderson, Anderson d.O. Souza, Gustavo D. Ferrari, Ana E.C.S. Azzolini, Gabriela Pereira-da-Silva, and Luciane C. Alberici 2020. "Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer" Cells 9, no. 3: 628.

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