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Article

Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer

1
Liquid Biopsy Analysis Unit, Oncomet, Health Research Institute of Santiago (IDIS), 15706 Santiago de Compostela, Spain
2
Faculty of Health Sciences, Universidad Autónoma de Chile, Talca 3460000, Chile
3
Instituto de Biomedicina (IBIOMED), CIBERESP, 24071 León, Spain
4
Group of Research on Gene-Environment-Health Interactions (GIIGAS), Universidad de León, 24071 León, Spain
5
Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
6
Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 514; https://doi.org/10.3390/cells9020514
Received: 31 January 2020 / Revised: 20 February 2020 / Accepted: 21 February 2020 / Published: 24 February 2020
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Cancers: Colorectal Cancer)
Natural killer cells (NK cells) play a major role in the immune response to cancer. An important element of NK target recognition is the binding of human leucocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Colorectal carcinoma (CRC) is one of the most common types of inflammation-based cancer. The purpose of the present study was to investigate the presence of KIR genes and HLA class I and II alleles in 1074 CRC patients and 1272 controls. We imputed data from single-nucleotide polymorphism (SNP) Illumina OncoArray to identify associations at HLA (HLA–A, B, C, DPB1, DQA1, DQB1, and DRB1) and KIRs (HIBAG and KIR*IMP, respectively). For association analysis, we used PLINK (v1.9), the PyHLA software, and R version 3.4.0. Only three SNP markers showed suggestive associations (p < 10−3; rs16896742, rs28367832, and rs9277952). The frequency of KIR2DS3 was significantly increased in the CRC patients compared to healthy controls (p < 0.005). Our results suggest that the implication of NK cells in CRC may not act through allele combinations in KIR and HLA genes. Much larger studies in ethnically homogeneous populations are needed to rule out the possible role of allelic combinations in KIR and HLA genes in CRC risk. View Full-Text
Keywords: KIR; colorectal carcinoma; HLA; KIR2DS3; SNP; imputation KIR; colorectal carcinoma; HLA; KIR2DS3; SNP; imputation
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MDPI and ACS Style

Diaz-Peña, R.; Mondelo-Macía, P.; Molina de la Torre, A.J.; Sanz-Pamplona, R.; Moreno, V.; Martín, V. Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer. Cells 2020, 9, 514. https://doi.org/10.3390/cells9020514

AMA Style

Diaz-Peña R, Mondelo-Macía P, Molina de la Torre AJ, Sanz-Pamplona R, Moreno V, Martín V. Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer. Cells. 2020; 9(2):514. https://doi.org/10.3390/cells9020514

Chicago/Turabian Style

Diaz-Peña, Roberto, Patricia Mondelo-Macía, Antonio J. Molina de la Torre, Rebeca Sanz-Pamplona, Víctor Moreno, and Vicente Martín. 2020. "Analysis of Killer Immunoglobulin-Like Receptor Genes in Colorectal Cancer" Cells 9, no. 2: 514. https://doi.org/10.3390/cells9020514

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