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Retinoic Acid and Its Derivatives in Skin

1
Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, Poland
2
Department of Hematology/Oncology, Clinic of Internal Medicine II, Jena University Hospital, 07747 Jena, Germany
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Institute of Molecular Cell Biology, Center for Molecular Biomedicine Jena (CMB), Jena University Hospital, 07747 Jena, Germany
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Department of Internal Medicine IV, Division of Gastroenterology, Hepatology and Infectious Disease, Jena University Hospital, Friedrich Schiller University of Jena, 07747 Jena, Germany
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Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
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Department of Medicine, Faculty of Medical Sciences and Health Sciences, Kazimierz Pulaski University of Technology and Humanities, 26-600 Radom, Poland
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Department of Oncology, Medical University of Warsaw, 01-163 Warsaw, Poland
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Department of Gynecology and Oncological Gynecology, Military Institute of Medicine, 01-163 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(12), 2660; https://doi.org/10.3390/cells9122660
Received: 27 October 2020 / Revised: 29 November 2020 / Accepted: 7 December 2020 / Published: 11 December 2020
(This article belongs to the Section Cell Nuclei: Function, Transport and Receptors)
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are involved in the regulation of cell growth and differentiation. Vitamin A derivatives have held promise in cancer treatment and ATRA is used in differentiation therapy of acute promyelocytic leukemia (APL). ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, and ichthyosis. Moreover, modulation of retinoic acid receptors and retinoid X (or rexinoid) receptors function may affect dermal cells. The studies using complex genetic models with various combinations of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) indicate that retinoic acid and its derivatives have therapeutic potential for a variety of serious dermatological disorders including some malignant conditions. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology. View Full-Text
Keywords: vitamin A; all-trans-retinoic acid; retinoic acid receptors; dermatology vitamin A; all-trans-retinoic acid; retinoic acid receptors; dermatology
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MDPI and ACS Style

Szymański, Ł.; Skopek, R.; Palusińska, M.; Schenk, T.; Stengel, S.; Lewicki, S.; Kraj, L.; Kamiński, P.; Zelent, A. Retinoic Acid and Its Derivatives in Skin. Cells 2020, 9, 2660. https://doi.org/10.3390/cells9122660

AMA Style

Szymański Ł, Skopek R, Palusińska M, Schenk T, Stengel S, Lewicki S, Kraj L, Kamiński P, Zelent A. Retinoic Acid and Its Derivatives in Skin. Cells. 2020; 9(12):2660. https://doi.org/10.3390/cells9122660

Chicago/Turabian Style

Szymański, Łukasz; Skopek, Rafał; Palusińska, Małgorzata; Schenk, Tino; Stengel, Sven; Lewicki, Sławomir; Kraj, Leszek; Kamiński, Paweł; Zelent, Arthur. 2020. "Retinoic Acid and Its Derivatives in Skin" Cells 9, no. 12: 2660. https://doi.org/10.3390/cells9122660

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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