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COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance

by 1 and 1,2,*
1
Cerebrovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
2
Department of Biomedical Engineering and Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(11), 2360; https://doi.org/10.3390/cells9112360
Received: 15 July 2020 / Revised: 16 October 2020 / Accepted: 26 October 2020 / Published: 27 October 2020
(This article belongs to the Section Cells of the Nervous System)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (COVID-19). The virus invades human cells through the angiotensin-converting enzyme 2 (ACE2) receptor-driven pathway, primarily targeting the human respiratory tract. However, emerging reports of neurological manifestations demonstrate the neuroinvasive potential of SARS-CoV-2. This review highlights the possible routes by which SARS-CoV-2 may invade the central nervous system (CNS) and provides insight into recent case reports of COVID-19-associated neurological disorders, namely ischaemic stroke, encephalitis, encephalopathy, epilepsy, neurodegenerative diseases, and inflammatory-mediated neurological disorders. We hypothesize that SARS-CoV-2 neuroinvasion, neuroinflammation, and blood-brain barrier (BBB) dysfunction may be implicated in the development of the observed disorders; however, further research is critical to understand the detailed mechanisms and pathway of infectivity behind CNS pathogenesis. View Full-Text
Keywords: CNS; COVID-19; SARS-CoV-2; blood-brain barrier; cerebrovascular; neurological disorders CNS; COVID-19; SARS-CoV-2; blood-brain barrier; cerebrovascular; neurological disorders
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MDPI and ACS Style

Achar, A.; Ghosh, C. COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance. Cells 2020, 9, 2360. https://doi.org/10.3390/cells9112360

AMA Style

Achar A, Ghosh C. COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance. Cells. 2020; 9(11):2360. https://doi.org/10.3390/cells9112360

Chicago/Turabian Style

Achar, Aneesha; Ghosh, Chaitali. 2020. "COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance" Cells 9, no. 11: 2360. https://doi.org/10.3390/cells9112360

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