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Review

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

1
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
2
Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong
3
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853-2703, USA
4
City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, Guangdong, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(10), 2191; https://doi.org/10.3390/cells9102191
Received: 23 April 2020 / Revised: 24 May 2020 / Accepted: 30 May 2020 / Published: 29 September 2020
(This article belongs to the Special Issue Therapeutic Applications of Extracellular Vesicles)
Despite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic delivery system with high target specificity upon systemic administration. In this respect, extracellular vesicles (EVs), as natural carriers of bioactive cargo, have emerged as a promising solution and can be further modified to improve their therapeutic efficacy. In this review, we provide an overview of the biogenesis pathways, biochemical features, and isolation methods of EVs with an emphasis on their many intrinsic properties that make them desirable as drug carriers. We then describe in detail the current advances in EV therapeutics, focusing on how EVs can be engineered to achieve improved target specificity, better circulation kinetics, and efficient encapsulation of therapeutic payloads. We also identify the challenges and obstacles ahead for clinical translation and provide an outlook on the future perspective of EV-based therapeutics. View Full-Text
Keywords: extracellular vesicles; drug delivery; therapeutic; clinical; translation extracellular vesicles; drug delivery; therapeutic; clinical; translation
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MDPI and ACS Style

Dang, X.T.T.; Kavishka, J.M.; Zhang, D.X.; Pirisinu, M.; Le, M.T.N. Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery. Cells 2020, 9, 2191. https://doi.org/10.3390/cells9102191

AMA Style

Dang XTT, Kavishka JM, Zhang DX, Pirisinu M, Le MTN. Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery. Cells. 2020; 9(10):2191. https://doi.org/10.3390/cells9102191

Chicago/Turabian Style

Dang, Xuan T. T., Jayasinghe Migara Kavishka, Daniel Xin Zhang, Marco Pirisinu, and Minh T. N. Le. 2020. "Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery" Cells 9, no. 10: 2191. https://doi.org/10.3390/cells9102191

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