Next Article in Journal
3D Stem Cell Culture
Next Article in Special Issue
Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury
Previous Article in Journal
GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells
Article

Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction

1
Siberian State Medical University, 634055 Tomsk, Russia
2
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012 Tomsk, Russia
3
National Research Tomsk State University, 634050 Tomsk, Russia
4
Institute of Transfusion Medicine and Immunology, University of Heidelberg, 1-3 Theodor-Kutzer Ufer, 68167 Mannheim, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2179; https://doi.org/10.3390/cells9102179
Received: 19 August 2020 / Revised: 24 September 2020 / Accepted: 25 September 2020 / Published: 27 September 2020
(This article belongs to the Special Issue Bone Morphogenetic Protein (BMP) Signaling in Health and Diseases)
Background: Bone morphogenetic proteins-2 and -4 (BMPs) have been implicated in left ventricular remodeling (LVR) processes such as an inflammation and fibrogenesis. We hypothesized that this knowledge could be translated into clinics. Methods: We studied the dynamics of serum levels of BMPs, its correlation with markers of LVR and with parameters of echocardiography in patients (n = 31) during the six-month follow-up period after myocardial infarction (MI). Results: Elevated serum levels of BMPs decreased by the six-month follow-up period. BMP-2 decreased from the first day after MI, and BMP-4 decreased from the Day 14. The elevated level of BMP-2 at Day 1 was associated with a lower level of troponin I, reperfusion time and better left ventricular ejection fraction (LV EF) at the six-month follow-up. Elevated serum level of BMP-4 at Day 1 was associated with a lower level of a soluble isoform of suppression of tumorigenicity 2 (sST2), age and reperfusion time. An elevated level of BMP-2 at the six-month follow-up was associated with higher levels of BMP-4, high-sensitivity C-reactive protein (hCRP) and sST2. High serum level of BMP-2 correlated with high levels of hCRP and matrix metalloproteinase (MMP)-9 on Day 7. High serum level of BMP-4 correlated with low levels of hCRP, MMP-9 at Day 3, sST2 at Day 1 and with decreased LV EF on Day 7. The findings of multivariate analysis support the involvement of BMP-2 in the development of post-infarction LVR. Conclusions: Our research translates experimental data about the BMPs in the development of adverse LVR into the clinic. Elevated serum levels of BMPs decreased by the end of the six-month period after MI. BMP-2 decreased from the first day and BMP-4 decreased from Day 14. BMP-2 and BMP-4 were associated with the development of LVR. Their correlations with markers of inflammation, degradation of the extracellular matrix, hemodynamic stress and markers of myocardial damage further support our hypothesis. Diagnostic and predictive values of these BMPs at the development of post-infarction LVR in vivo should be investigated further. View Full-Text
Keywords: myocardial infarction; BMP-2; BMP-4; macrophages; adverse left ventricular remodeling myocardial infarction; BMP-2; BMP-4; macrophages; adverse left ventricular remodeling
Show Figures

Graphical abstract

MDPI and ACS Style

Kercheva, M.; Gusakova, A.M.; Ryabova, T.R.; Suslova, T.E.; Kzhyshkowska, J.; Ryabov, V.V. Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction. Cells 2020, 9, 2179. https://doi.org/10.3390/cells9102179

AMA Style

Kercheva M, Gusakova AM, Ryabova TR, Suslova TE, Kzhyshkowska J, Ryabov VV. Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction. Cells. 2020; 9(10):2179. https://doi.org/10.3390/cells9102179

Chicago/Turabian Style

Kercheva, Maria, Anna M. Gusakova, Tamara R. Ryabova, Tatiana E. Suslova, Julia Kzhyshkowska, and Vyacheslav V. Ryabov 2020. "Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction" Cells 9, no. 10: 2179. https://doi.org/10.3390/cells9102179

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop