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Open AccessReview

Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes

1
State Key Laboratory of Natural and Biomimetic Drugs, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
2
Institute of Microelectronics, Peking University, Beijing 100871, China
*
Author to whom correspondence should be addressed.
Received: 14 November 2019 / Revised: 13 December 2019 / Accepted: 16 December 2019 / Published: 18 December 2019
(This article belongs to the Special Issue Stem Cell Research on Cardiology)
Heart diseases such as myocardial infarction and myocardial ischemia are paroxysmal and fatal in clinical practice. Cardiomyocytes (CMs) differentiated from human pluripotent stem cells provide a promising approach to myocardium regeneration therapy. Identifying the maturity level of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is currently the main challenge for pathophysiology and therapeutics. In this review, we describe current maturity indicators for cardiac microtissue and microdevice cultivation technologies that accelerate cardiac maturation. It may provide insights into regenerative medicine, drug cardiotoxicity testing, and preclinical safety testing. View Full-Text
Keywords: human pluripotent stem cell; cardiomyocytes; ventricular; cardiac tissue engineering; maturation human pluripotent stem cell; cardiomyocytes; ventricular; cardiac tissue engineering; maturation
MDPI and ACS Style

Ge, F.; Wang, Z.; Xi, J.J. Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes. Cells 2020, 9, 9. https://doi.org/10.3390/cells9010009

AMA Style

Ge F, Wang Z, Xi JJ. Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes. Cells. 2020; 9(1):9. https://doi.org/10.3390/cells9010009

Chicago/Turabian Style

Ge, Feixiang; Wang, Zetian; Xi, Jianzhong J. 2020. "Engineered Maturation Approaches of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes" Cells 9, no. 1: 9. https://doi.org/10.3390/cells9010009

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