Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Abstract
:1. Introduction
2. The Role of Human Antigen R (HuR) in Colon Carcinogenesis
2.1. HuR: A Unique Post-Transcriptional Regulator of Cell Survival
2.2. Negative Caspase-2 Regulation by HuR as a Novel Survival Mechanism in Adenocarcinoma Cells
2.3. HuR Affects Internal Ribosome Entry Site (IRES) Mediated Caspase-2 Translation
2.4. HuR as a Potential Negative IRES Trans-Acting Factor (ITAF) of Caspase-2 Translation
3. Regulation of the DNA Damage Response by the HuR-Caspase-2 Axis
3.1. HuR and the DNA Damage Response
3.2. Role of Caspase-2 in DNA Damage-Induced Apoptosis
3.3. Caspase-2 Acts as a Guardian of Genomic Stability
4. Concluding Remarks
Funding
Acknowledgments
Conflicts of Interest
References
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Eberhardt, W.; Nasrullah, U.; Haeussler, K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells? Cells 2019, 8, 797. https://doi.org/10.3390/cells8080797
Eberhardt W, Nasrullah U, Haeussler K. Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells? Cells. 2019; 8(8):797. https://doi.org/10.3390/cells8080797
Chicago/Turabian StyleEberhardt, Wolfgang, Usman Nasrullah, and Kristina Haeussler. 2019. "Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?" Cells 8, no. 8: 797. https://doi.org/10.3390/cells8080797