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Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask)

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(4), 357; https://doi.org/10.3390/cells8040357
Received: 19 February 2019 / Revised: 26 March 2019 / Accepted: 12 April 2019 / Published: 16 April 2019
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
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Abstract

The beta-3 adrenergic receptor (β3-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of β3-AR is unraveling quickly. As will become evident in this work, β3-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease. In this review, we will discuss the most recent advances regarding β3-AR signaling and function and summarize how these findings translate, or may do so, into current clinical practice highlighting β3-AR’s great potential as a novel therapeutic target in a wide range of human conditions. View Full-Text
Keywords: beta-3 adrenergic receptor; therapeutic target; G-protein coupled receptors beta-3 adrenergic receptor; therapeutic target; G-protein coupled receptors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Schena, G.; Caplan, M.J. Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask). Cells 2019, 8, 357.

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