Next Article in Journal
The Nuclear Lamina as an Organizer of Chromosome Architecture
Previous Article in Journal
MiRNAs from DLK1-DIO3 Imprinted Locus at 14q32 are Associated with Multiple Sclerosis: Gender-Specific Expression and Regulation of Receptor Tyrosine Kinases Signaling
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Cells 2019, 8(2), 134; https://doi.org/10.3390/cells8020134

Megakaryocytes in Bone Metastasis: Protection or Progression?

IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy
Received: 5 December 2018 / Revised: 4 February 2019 / Accepted: 5 February 2019 / Published: 8 February 2019
Full-Text   |   PDF [2134 KB, uploaded 8 February 2019]   |  

Abstract

Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain characteristics are able to reach secondary growth sites. Platelets play a pivotal role in tumour growth, by conferring resistance to shear stress to the circulating tumour cells and protection against natural killer cell attack. Mature polyploid megakaryocytes (MKs) reside in close proximity to the vascular sinusoids of bone marrow, where their primary function is to produce platelets. Emerging evidence has demonstrated that MKs are essential for skeletal homeostasis, due to the expression and production of the bone-related proteins osteocalcin, osteonectin, bone morphogenetic protein, osteopontin, bone sialoprotein, and osteoprotegerin. Debate surrounds the role that MKs play in the development of bone metastasis, which is the topic of this mini-review. View Full-Text
Keywords: megakaryocytes; bone metastasis; bone marrow; microenvironment; platelets megakaryocytes; bone metastasis; bone marrow; microenvironment; platelets
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Maroni, P. Megakaryocytes in Bone Metastasis: Protection or Progression? Cells 2019, 8, 134.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top