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Open AccessArticle

The Relationship Between the miRNA Sequence and Disease May be Revealed by Focusing on Hydrogen Bonding Sites in RNA–RNA Interactions

1
School of Materials and Chemical Technology, Tokyo Institute of Technology, Yokohama 226-8502, Japan
2
Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo 152-8550, Japan
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1615; https://doi.org/10.3390/cells8121615
Received: 30 October 2019 / Revised: 26 November 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
(This article belongs to the Special Issue microRNA Bioinformatics)
MicroRNAs are important genes in biological processes. Although the function of microRNAs has been elucidated, the relationship between the sequence and the disease is not sufficiently clear. It is important to clarify the relationship between the sequence and the disease because it is possible to clarify the meaning of the microRNA genetic code consisting of four nucleobases. Since seed theory is based on sequences, its development can be expected to reveal the meaning of microRNA sequences. However, this method has many false positives and false negatives. On the other hand, disease-related microRNA searches using network analysis are not based on sequences, so it is difficult to clarify the relationship between sequences and diseases. Therefore, RNA–RNA interactions which are caused by hydrogen bonding were focused on. As a result, it was clarified that sequences and diseases were highly correlated by calculating the electric field in microRNA which is considered as the torus. It was also suggested that four diseases with different major classifications can be distinguished. Conventionally, RNA was interpreted as a one-dimensional array of four nucleobases, but a new approach to RNA from this study can be expected to provide a new perspective on RNA-RNA interactions. View Full-Text
Keywords: microRNA; regression analysis; hydrogen bond; disease microRNA; regression analysis; hydrogen bond; disease
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Osone, T.; Yoshida, N. The Relationship Between the miRNA Sequence and Disease May be Revealed by Focusing on Hydrogen Bonding Sites in RNA–RNA Interactions. Cells 2019, 8, 1615.

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