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Review

Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells

Laboratory of Immunology and Cellular Stress, Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(12), 1563; https://doi.org/10.3390/cells8121563
Received: 1 November 2019 / Revised: 22 November 2019 / Accepted: 24 November 2019 / Published: 4 December 2019
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Stress Responses)
The unfolded protein response (UPR) is an adaptive response that maintains the fidelity of the cellular proteome in conditions that subvert the folding capacity of the cell, such as those noticed in infection and inflammatory contexts. In immunity, the UPR sensor IRE1 (Inositol-requiring enzyme 1-alpha) has emerged as a critical regulator of the homeostasis of antigen presenting cells (APCs). In the past few years, it has become clear that IRE1 plays canonical and non-canonical roles in APCs, many of which intersect with key features of these cells, including the initiation of inflammation, antibody production, and antigen presentation. The aims of the present review are to provide recent insights on the mechanisms by which IRE1 regulates the diversity of APC functions and to highlight its relevance in the coordination of innate and adaptive immunity. View Full-Text
Keywords: unfolded protein response; immunity; antigen presenting cell; inflammation; infection unfolded protein response; immunity; antigen presenting cell; inflammation; infection
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MDPI and ACS Style

Flores-Santibáñez, F.; Medel, B.; Bernales, J.I.; Osorio, F. Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells. Cells 2019, 8, 1563. https://doi.org/10.3390/cells8121563

AMA Style

Flores-Santibáñez F, Medel B, Bernales JI, Osorio F. Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells. Cells. 2019; 8(12):1563. https://doi.org/10.3390/cells8121563

Chicago/Turabian Style

Flores-Santibáñez, Felipe, Bernardita Medel, José I. Bernales, and Fabiola Osorio. 2019. "Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells" Cells 8, no. 12: 1563. https://doi.org/10.3390/cells8121563

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