Next Article in Journal
Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells
Next Article in Special Issue
CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies
Previous Article in Journal
Synovial-Fluid miRNA Signature for Diagnosis of Juvenile Idiopathic Arthritis
Open AccessReview

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab

1
Hematology/Oncology, University of California San Francisco, San Francisco, CA 94143-0324, USA
2
Sanofi Oncology, Cambridge, MA 02142, USA
3
Translational and Experimental Medicine, Sanofi Research & Development, 94403 Vitry-sur-Seine, France
4
Integrated Drug Discovery, Sanofi Research & Development, 94403 Vitry-sur-Seine, France
5
Dana-Farber Cancer Institute, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1522; https://doi.org/10.3390/cells8121522
Received: 31 October 2019 / Revised: 22 November 2019 / Accepted: 23 November 2019 / Published: 26 November 2019
CD38 is a transmembrane glycoprotein with ectoenzymatic activity involved in regulation of migration, signal transduction, and receptor-mediated adhesion. CD38 is highly expressed on various malignant cells, including multiple myeloma (MM), and at relatively low levels in other tissues, making it a suitable target for therapeutic antibodies. Several anti-CD38 therapies have been, or are being, developed for the treatment of MM, including daratumumab and isatuximab (SAR650984), respectively. Studies have shown that anti-CD38 therapies are effective in the treatment of relapsed/refractory MM and are well tolerated, with infusion reactions being the most common side effects. They can be used as monotherapy or in combination with immunomodulatory agents, such as pomalidomide, or proteasome inhibitors to potentiate their activity. Here we examine isatuximab and several anti-CD38 agents in development that were generated using new antibody engineering techniques and that may lead to more effective CD38 targeting. We also summarize trials assessing these antibodies in MM, other malignancies, and solid organ transplantation. Finally, we propose that further research on the mechanisms of resistance to anti-CD38 therapy and the development of biomarkers and new backbone regimens with CD38 antibodies will be important steps in building more personalized treatment for patients with MM. View Full-Text
Keywords: multiple myeloma; anti-CD38 therapy; isatuximab multiple myeloma; anti-CD38 therapy; isatuximab
Show Figures

Figure 1

MDPI and ACS Style

Martin, T.G.; Corzo, K.; Chiron, M.; van de Velde, H.; Abbadessa, G.; Campana, F.; Solanki, M.; Meng, R.; Lee, H.; Wiederschain, D.; Zhu, C.; Rak, A.; Anderson, K.C. Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab. Cells 2019, 8, 1522.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop