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Cells
Volume 8
Issue 10
10.3390/cells8101162
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Article

Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

by
Andreas Keller
1,2,*,
Nicole Ludwig
3,4,
Tobias Fehlmann
1,
Mustafa Kahraman
1,
Christina Backes
1,
Fabian Kern
1,
Claus F. Vogelmeier
5,
Caroline Diener
3,
Ulrike Fischer
3,
Frank Biertz
6,
Christian Herr
7,
Rudolf A. Jörres
8,
Hans-Peter Lenhof
9,
Robert Bals
7 and
Eckart Meese
3
1
Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany
2
School of Medicine Office, Stanford University, Stanford, CA 94305, USA
3
Department of Human Genetics, Saarland University Hospital, 66421 Homburg, Germany
4
Center for Human and Molecular Biology, Saarland University, 66421 Homburg, Germany
5
Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Baldingerstrasse, 35043 Marburg, Germany
6
Institute for Biostatistics, Hannover Medical School, 30625 Hanover, Germany
7
Department of Internal Medicine V–Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, 66421 Homburg, Germany
8
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ziemssenstrasse 1, 80336 Munich, Germany
9
Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Germany
*
Author to whom correspondence should be addressed.
Cells 2019, 8(10), 1162; https://doi.org/10.3390/cells8101162
Received: 31 August 2019 / Revised: 24 September 2019 / Accepted: 25 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue microRNA as Biomarker)
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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork” (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients. View Full-Text
Keywords: miRNA; COPD; cancer; survival miRNA; COPD; cancer; survival
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MDPI and ACS Style

Keller, A.; Ludwig, N.; Fehlmann, T.; Kahraman, M.; Backes, C.; Kern, F.; Vogelmeier, C.F.; Diener, C.; Fischer, U.; Biertz, F.; Herr, C.; Jörres, R.A.; Lenhof, H.-P.; Bals, R.; Meese, E. Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. Cells 2019, 8, 1162. https://doi.org/10.3390/cells8101162

AMA Style

Keller A, Ludwig N, Fehlmann T, Kahraman M, Backes C, Kern F, Vogelmeier CF, Diener C, Fischer U, Biertz F, Herr C, Jörres RA, Lenhof H-P, Bals R, Meese E. Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. Cells. 2019; 8(10):1162. https://doi.org/10.3390/cells8101162

Chicago/Turabian Style

Keller, Andreas, Nicole Ludwig, Tobias Fehlmann, Mustafa Kahraman, Christina Backes, Fabian Kern, Claus F. Vogelmeier, Caroline Diener, Ulrike Fischer, Frank Biertz, Christian Herr, Rudolf A. Jörres, Hans-Peter Lenhof, Robert Bals, and Eckart Meese. 2019. "Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients" Cells 8, no. 10: 1162. https://doi.org/10.3390/cells8101162

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