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Cells 2018, 7(7), 82; https://doi.org/10.3390/cells7070082

TRPM2 in the Brain: Role in Health and Disease

Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
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Received: 8 June 2018 / Revised: 10 July 2018 / Accepted: 20 July 2018 / Published: 22 July 2018
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
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Abstract

Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies. View Full-Text
Keywords: TRPM2; brain; aging; neurodegeneration; neurodegenerative disease TRPM2; brain; aging; neurodegeneration; neurodegenerative disease
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Sita, G.; Hrelia, P.; Graziosi, A.; Ravegnini, G.; Morroni, F. TRPM2 in the Brain: Role in Health and Disease. Cells 2018, 7, 82.

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