TRPM2 in the Brain: Role in Health and Disease
AbstractTransient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies. View Full-Text
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Sita, G.; Hrelia, P.; Graziosi, A.; Ravegnini, G.; Morroni, F. TRPM2 in the Brain: Role in Health and Disease. Cells 2018, 7, 82.
Sita G, Hrelia P, Graziosi A, Ravegnini G, Morroni F. TRPM2 in the Brain: Role in Health and Disease. Cells. 2018; 7(7):82.Chicago/Turabian Style
Sita, Giulia; Hrelia, Patrizia; Graziosi, Agnese; Ravegnini, Gloria; Morroni, Fabiana. 2018. "TRPM2 in the Brain: Role in Health and Disease." Cells 7, no. 7: 82.
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