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Cells 2018, 7(7), 75; https://doi.org/10.3390/cells7070075

Cell Signaling in Neuronal Stem Cells

1
Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia
2
School of Medicine, Universidad Rafael Nuñez, Cartagena 130001, Colombia
3
Centro de Investigación en Salud para el Trópico, Universidad Cooperativa de Colombia, Santa Marta 470002, Colombia
4
School of Medicine, Universidad Libre, Barranquilla 080002, Colombia
5
School of Medicine, Universidad de Cadiz, Cadiz 110003, Spain
6
Clinica de la Costa, Barranquilla 080002, Colombia
*
Author to whom correspondence should be addressed.
Received: 1 June 2018 / Revised: 30 June 2018 / Accepted: 12 July 2018 / Published: 14 July 2018
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Abstract

The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors). View Full-Text
Keywords: neural stem cell; Wnt/beta-Catenin; differentiation neural stem cell; Wnt/beta-Catenin; differentiation
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Navarro Quiroz, E.; Navarro Quiroz, R.; Ahmad, M.; Gomez Escorcia, L.; Villarreal, J.L.; Fernandez Ponce, C.; Aroca Martinez, G. Cell Signaling in Neuronal Stem Cells. Cells 2018, 7, 75.

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