Next Article in Journal
Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer
Previous Article in Journal
TRP Channel Involvement in Salivary Glands—Some Good, Some Bad
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Cells 2018, 7(7), 75;

Cell Signaling in Neuronal Stem Cells

Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia
School of Medicine, Universidad Rafael Nuñez, Cartagena 130001, Colombia
Centro de Investigación en Salud para el Trópico, Universidad Cooperativa de Colombia, Santa Marta 470002, Colombia
School of Medicine, Universidad Libre, Barranquilla 080002, Colombia
School of Medicine, Universidad de Cadiz, Cadiz 110003, Spain
Clinica de la Costa, Barranquilla 080002, Colombia
Author to whom correspondence should be addressed.
Received: 1 June 2018 / Revised: 30 June 2018 / Accepted: 12 July 2018 / Published: 14 July 2018
Full-Text   |   PDF [1082 KB, uploaded 14 July 2018]   |  


The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors). View Full-Text
Keywords: neural stem cell; Wnt/beta-Catenin; differentiation neural stem cell; Wnt/beta-Catenin; differentiation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Navarro Quiroz, E.; Navarro Quiroz, R.; Ahmad, M.; Gomez Escorcia, L.; Villarreal, J.L.; Fernandez Ponce, C.; Aroca Martinez, G. Cell Signaling in Neuronal Stem Cells. Cells 2018, 7, 75.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top