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Cells 2018, 7(12), 243; https://doi.org/10.3390/cells7120243

lncRNA-Six1 Is a Target of miR-1611 That Functions as a ceRNA to Regulate Six1 Protein Expression and Fiber Type Switching in Chicken Myogenesis

1,2,3,†
,
1,2,3,†
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3,* and 1,2,3
1
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China
2
Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China
3
National-Local Joint Engineering Research Center for Livestock Breeding, Guangzhou 510642, Guangdong, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 October 2018 / Revised: 23 November 2018 / Accepted: 4 December 2018 / Published: 4 December 2018
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Abstract

Emerging studies indicate important roles for non-coding RNAs (ncRNAs) as essential regulators in myogenesis, but relatively less is known about their function. In our previous study, we found that lncRNA-Six1 can regulate Six1 in cis to participate in myogenesis. Here, we studied a microRNA (miRNA) that is specifically expressed in chickens (miR-1611). Interestingly, miR-1611 was found to contain potential binding sites for both lncRNA-Six1 and Six1, and it can interact with lncRNA-Six1 to regulate Six1 expression. Overexpression of miR-1611 represses the proliferation and differentiation of myoblasts. Moreover, miR-1611 is highly expressed in slow-twitch fibers, and it drives the transformation of fast-twitch muscle fibers to slow-twitch muscle fibers. Together, these data demonstrate that miR-1611 can mediate the regulation of Six1 by lncRNA-Six1, thereby affecting proliferation and differentiation of myoblasts and transformation of muscle fiber types. View Full-Text
Keywords: miR-1611; lncRNA-Six1; Six1; myoblast proliferation; myoblast differentiation; transformation of muscle fiber types miR-1611; lncRNA-Six1; Six1; myoblast proliferation; myoblast differentiation; transformation of muscle fiber types
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Ma, M.; Cai, B.; Jiang, L.; Abdalla, B.A.; Li, Z.; Nie, Q.; Zhang, X. lncRNA-Six1 Is a Target of miR-1611 That Functions as a ceRNA to Regulate Six1 Protein Expression and Fiber Type Switching in Chicken Myogenesis. Cells 2018, 7, 243.

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