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Cells 2018, 7(11), 185; https://doi.org/10.3390/cells7110185

The Association of XRCC1 Gene Polymorphisms and Chronic Hepatitis C Induced Insulin Resistance in Egyptian Patients

1
Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
2
Department of Tropical medicine, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
3
Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 23 September 2018 / Accepted: 23 October 2018 / Published: 25 October 2018
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Abstract

Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR related to chronic hepatitis C virus (HCV) infection in Egyptian patients. In a case-control study, a total of 210 subjects, including 140 chronic HCV patients (87 patients with IR and 53 without IR) and 70 healthy controls, were included. Two genetic polymorphisms (c.1254C > T and c.1517G > C) of the XRCC1 gene were genotyped via the PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The result of the current study revealed that these two single nucleotide polymorphisms (SNPs) have statistically significant influences on susceptibility to IR in chronic HCV infected Egyptian patients. It could be concluded that c.1254C > T, the TT genotype, CT/CC carriers as well as c.1517G > C, the CC genotype and GC/GG carriers might be associated with increased IR susceptibility. Moreover, T-allele of c.1254C > T and the C-allele of c.1517G > C genetic variants might influence the susceptibility. View Full-Text
Keywords: XRCC1 gene; polymorphisms; insulin resistance; HCV XRCC1 gene; polymorphisms; insulin resistance; HCV
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Abo El-khair, S.M.; Arafa, M.; Besheer, T.; El-Eraky, A.M.; Elsamanoudy, A.Z. The Association of XRCC1 Gene Polymorphisms and Chronic Hepatitis C Induced Insulin Resistance in Egyptian Patients. Cells 2018, 7, 185.

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