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The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1

Airway Epithelial Cell Cilia and Obstructive Lung Disease

by 1,3 and 1,2,3,*
Firestone Research Aerosol Laboratory, Fontbonne Bldg. Room F132, Hamilton, ON L8N 4A6, Canada
Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada
St. Joseph’s Healthcare, Firestone Institute for Respiratory Health, 50 Charlton Ave East, FIRH Room T2135, Hamilton, ON L8N 4A6, Canada
Author to whom correspondence should be addressed.
Academic Editors: Gang Dong and William Tsang
Cells 2016, 5(4), 40;
Received: 1 August 2016 / Revised: 27 October 2016 / Accepted: 7 November 2016 / Published: 11 November 2016
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in transporting secretions out of the lung, the mucociliary transport apparatus must exhibit a cohesive beating of all ciliated epithelial cells that line the upper and lower respiratory tract. Cilia function can be modulated by exposures to endogenous and exogenous factors and by the viscosity of the mucus lining the epithelium. Cilia function is impaired in lung diseases such as COPD and asthma, and pharmacologic agents can modulate cilia function and mucus viscosity. Cilia beating is reduced in COPD, however, more research is needed to determine the structural-functional regulation of ciliary beating via all signaling pathways and how this might relate to the initiation or progression of obstructive lung diseases. Additionally, genotypes and how these can influence phenotypes and epithelial cell cilia function and structure should be taken into consideration in future investigations. View Full-Text
Keywords: epithelium; lung disease; ciliary function; COPD; inflammation; cilia epithelium; lung disease; ciliary function; COPD; inflammation; cilia
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MDPI and ACS Style

Yaghi, A.; Dolovich, M.B. Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells 2016, 5, 40.

AMA Style

Yaghi A, Dolovich MB. Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells. 2016; 5(4):40.

Chicago/Turabian Style

Yaghi, Asma, and Myrna B. Dolovich. 2016. "Airway Epithelial Cell Cilia and Obstructive Lung Disease" Cells 5, no. 4: 40.

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