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Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions

NF-κB, Differentiation and Cancer, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France
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Academic Editor: Ruaidhri Carmody
Cells 2016, 5(2), 22; https://doi.org/10.3390/cells5020022
Received: 11 March 2016 / Revised: 19 April 2016 / Accepted: 26 April 2016 / Published: 4 May 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-κB activation pathway, a second NF-κB pathway has more recently been uncovered, the so-called alternative NF-κB activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-κB family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-κB. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions. View Full-Text
Keywords: NF-kappaB; RelB; post-translational modifications; cell motility; phosphorylation; ubiquitination; SUMOylation; NF-κB alternative pathway NF-kappaB; RelB; post-translational modifications; cell motility; phosphorylation; ubiquitination; SUMOylation; NF-κB alternative pathway
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Baud, V.; Collares, D. Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions. Cells 2016, 5, 22.

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