Next Article in Journal
Condensins are Required for Maintenance of Nuclear Architecture
Next Article in Special Issue
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Previous Article in Journal / Special Issue
Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin
Article Menu

Export Article

Open AccessReview

Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition

Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku 4-6-1, Tokyo 108-8639, Japan
Picobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, Japan
Author to whom correspondence should be addressed.
Cells 2014, 3(3), 848-864;
Received: 17 March 2014 / Revised: 12 July 2014 / Accepted: 21 July 2014 / Published: 18 August 2014
(This article belongs to the Special Issue Protein Ubiquitination)
PDF [4984 KB, uploaded 19 August 2014]


Protein ubiquitination plays indispensable roles in the regulation of cell homeostasis and pathogenesis of neoplastic, infectious, and neurodegenerative diseases. Given the importance of this modification, it is to be expected that several pathogenic bacteria have developed the ability to utilize the host ubiquitin system for their own benefit. Modulation of the host ubiquitin system by bacterial effector proteins inhibits innate immune responses and hijacks central signaling pathways. Bacterial effectors mimic enzymes of the host ubiquitin system, but may or may not be structurally similar to the mammalian enzymes. Other effectors bind and modify components of the host ubiquitin system, and some are themselves subject to ubiquitination. This review will describe recent findings, based on structural analyses, regarding how pathogens use post-translational modifications of proteins to establish an infection. View Full-Text
Keywords: ubiquitin; effector; structure; pathogenic bacteria ubiquitin; effector; structure; pathogenic bacteria
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Kim, M.; Otsubo, R.; Morikawa, H.; Nishide, A.; Takagi, K.; Sasakawa, C.; Mizushima, T. Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition. Cells 2014, 3, 848-864.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top