TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy
Abstract
:1. Introduction
2. Results and Discussion
2.1. Effects of Visible Light on TRPV
2.1.1. TRPV1 as Target for Irradiation
Red-Laser Irradiation | Green-Laser Irradiation | IR-Laser Irratiation | UV-Laser Irradiation | |
---|---|---|---|---|
Wavelength | 650 nm | 532 nm | 1.8–2.8 µm | ≈300 nm |
Power density (mW/cm2) | ≤500 | ≤500 | <3 × 106 [20] <7 × 103 [21] | 15 × 103 [22] 0.3 [23] |
TRPV1 (current increase at −60 mV) | 2.6 ± 0.5 [18] | 4.7 ± 0.2 [18] | − heat avided [20] | + [23] |
TRPV2 (current increase at −60 mV) | 1.9 ± 0.5 [15] | n.a. | n.a. | n.a. |
TRPV4 (current increase at −60 mV) | n.a. | ≈3.7 * | + heat induced [21] − heat avided [20] | + [22] |
2.1.2. TRPV2 as Target for Irradiation
2.1.3. TRPV4 as Target for Irradiation
2.2. Effects of IR Light on TRPV
2.3. Effects of UV Light on TRPV
2.4. TRPV Modulation and Mast-Cell Activation
2.5. Effect of Laser Irradiation on Intracellular Ca2+ Activity and ATP Release Mobilisation
2.6. Underlying Mechanisms for Laser-Light-Induced TRPV Modulation
3. Conclusions
Acknowledgments
Conflicts of Interest
References
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Wang, L.; Zhang, D.; Schwarz, W. TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy. Cells 2014, 3, 662-673. https://doi.org/10.3390/cells3030662
Wang L, Zhang D, Schwarz W. TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy. Cells. 2014; 3(3):662-673. https://doi.org/10.3390/cells3030662
Chicago/Turabian StyleWang, Lina, Di Zhang, and Wolfgang Schwarz. 2014. "TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy" Cells 3, no. 3: 662-673. https://doi.org/10.3390/cells3030662