Next Article in Journal
Correction: Liberati, S., et al. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells 2014, 3, 112–128
Previous Article in Journal
The Challenge of Producing Ubiquitinated Proteins for Structural Studies
Previous Article in Special Issue
Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy
Article Menu

Export Article

Open AccessEditorial
Cells 2014, 3(2), 657-659;

Receptor Tyrosine Kinases — Expanding Horizons

School of Pharmacy and Biomedical Sciences, Division of Pharmacology, University of Portsmouth, UK
Received: 11 June 2014 / Accepted: 12 June 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
Full-Text   |   PDF [143 KB, uploaded 20 June 2014]
Note: In lieu of an abstract, this is an excerpt from the first page.


This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules. The review by Julien et al. [1] is an overview of the knowledge on how gangliosides, constituting certain membrane microdomains, may interact with and regulate RTK activation and downstream signalling. Similarly, the review by Banning et al. [2] focuses on the influence of another type of membrane microdomain, namely that containing flotillins, on regulation of RTK signalling and its relevance to cancer. Both of these reviews provide novel insights into mechanisms of transmembrane receptor signalling that rely on the constitution of the microdomains the RTKs reside in, and how their modification may affect receptor clustering, activation and translocation. Thus, knowledge about such microdomains and their interactions with RTKs can provide new information on common regulation pathways starting at the membrane level, which could have implications for novel therapeutic angles in, e.g., cancer. [...] View Full-Text
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Hafizi, S. Receptor Tyrosine Kinases — Expanding Horizons. Cells 2014, 3, 657-659.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top