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Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Laborotary of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, HsinChu 30013, Taiwan
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Cells 2013, 2(4), 635-688; https://doi.org/10.3390/cells2040635
Received: 16 April 2013 / Revised: 12 September 2013 / Accepted: 19 September 2013 / Published: 11 October 2013
(This article belongs to the Special Issue Feature Papers 2013)
Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived from insight into: (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This review describes current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers. We also discuss challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering. View Full-Text
Keywords: systems biology; bioinformatics; systems synthetic biology; systems metabolic engineering systems biology; bioinformatics; systems synthetic biology; systems metabolic engineering
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Chen, B.-S.; Wu, C.-C. Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering. Cells 2013, 2, 635-688.

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